High-fat diet-induced reduction of peroxisome proliferator-activated receptor-γ coactivator-1α messenger RNA levels and oxidative capacity in the soleus muscle of rats with metabolic syndrome

Nutrition Research
Fumiko NagatomoAkihiko Ishihara

Abstract

Animal models of type 2 diabetes exhibit reduced peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) messenger RNA (mRNA) levels, which are associated with decreased oxidative capacity, in skeletal muscles. In contrast, animal models with metabolic syndrome show normal PGC-1α mRNA levels. We hypothesized that a high-fat diet decreases PGC-1α mRNA levels in skeletal muscles of rats with metabolic syndrome, reducing muscle oxidative capacity and accelerating metabolic syndrome or inducing type 2 diabetes. We examined mRNA levels and fiber profiles in the soleus muscles of rats with metabolic syndrome (SHR/NDmcr-cp [cp/cp]; CP) fed a high-fat diet. Five-week-old CP rats were assigned to a sedentary group (CP-N) that was fed a standard diet (15.1 kJ/g, 23.6% protein, 5.3% fat, and 54.4% carbohydrates) or a sedentary group (CP-H) that was fed a high-fat diet (21.6 kJ/g, 23.6% protein, 34.9% fat, and 25.9% carbohydrates) and were housed for 10 weeks. Body weight, energy intake, and systolic blood pressure were higher in the CP-H group than in the CP-N group. Nonfasting glucose, triglyceride, total cholesterol, and leptin levels were higher in the CP-H group than in the CP-N group. There was no difference in insulin l...Continue Reading

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Citations

Apr 20, 2014·The Journal of Nutritional Biochemistry·Reilly T EnosE Angela Murphy
Mar 12, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tenna JørgensenBjørn Quistorff
Oct 14, 2014·Muscle & Nerve·Akihiko IshiharaNoriaki Ishioka
Oct 16, 2018·Journal of Cellular Biochemistry·Mai M HasanEman M A Abdelghany
Jan 16, 2014·American Journal of Physiology. Endocrinology and Metabolism·Blair E WarrenHélène Lemieux
Jul 3, 2019·Journal of Muscle Research and Cell Motility·Akihiko Ishihara
May 31, 2016·Journal of Atherosclerosis and Thrombosis·Ai Takemura, Akihiko Ishihara
May 8, 2019·The Journal of Physiological Sciences : JPS·Akihiko Ishihara
May 31, 2019·Chinese Journal of Integrative Medicine·Hyun-Jung ParkInsop Shim

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