High-fat diet negatively impacts both metabolic and behavioral health in outbred heterogeneous stock rats.

Physiological Genomics
Aaron DealLeah C Solberg Woods

Abstract

Obesity is influenced by genetics and diet and has wide ranging comorbidities, including anxiety and depressive disorders. Outbred heterogeneous stock (HS) rats are used for fine-genetic mapping of complex traits and may be useful for understanding gene by diet interactions. In this study, HS rats were fed diets containing 60% kcal from fat (high-fat diet, HFD) or 10% kcal from fat (low-fat diet, LFD) and tested for metabolic (study 1) and behavioral (study 2) outcomes. In study 1, we measured glucose tolerance, fasting glucose and insulin, fat pad weights and despair-like behavior in the forced swim test (FST). In study 2, we assessed anxiety-like (elevated plus maze, EPM; open field test, OFT) and despair-like/coping (splash test, SpT; and FST) behaviors. Body weight and food intake were measured weekly in both studies. We found negative effects of HFD on metabolic outcomes, including increased body weight and fat pad weights, decreased glucose tolerance, and increased fasting insulin. We also found negative effects of HFD on despair-like/coping and anxiety-like behaviors. These include increased immobility in the FST, decreased open arm time in the EPM, and increased movement and rest episodes and decreased rearing in the OF...Continue Reading

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Citations

May 4, 2021·Frontiers in Behavioral Neuroscience·Alex L DealEvgeny A Budygin
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Benjamin ZimmermanJacob Raber

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Datasets Mentioned

BETA
13673907

Methods Mentioned

BETA
ELISA

Software Mentioned

Prism
Omnitech
GraphPad
lme4

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