High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice

Brain Research
Sheng-Feng TsaiYu-Min Kuo

Abstract

Metabolic disorders induce adverse effects on brain functions. The hippocampus is one of the most vulnerable regions to metabolic disorders. Disrupted neuroplasticity is a major cause of hippocampus-related behavioral impairments, including memory loss, anxiety, and depression. Astrocytes support processes of neuroplasticity. However, whether metabolic disorders induce changes in astrocytes and their roles in affective disorders is relatively unclear. To answer this question, we fed 8-week-old male C57BL/6 mice with a high-fat diet (HFD) for 12 weeks to induce metabolic disruption and then examined their performance of hippocampus-related memory, and anxiety- and depression-like behaviors. The morphology of astrocytes and the expression of astrocytic neuroplasticity-related proteins in the hippocampus were also assessed. The results showed that HFD led to obesity, systemic insulin resistance and dysregulated lipid metabolism in mice. HFD induced depression-like behaviors, but not anxiety or memory impairment. Furthermore, HFD increased the expression of GFAP, shortened the processes of GFAP+ cells, and downregulated the expression of astrocytic neuroplasticity-related protein, GLAST, GLT-1, and connexin-43 in the hippocampi. In...Continue Reading

Citations

Sep 26, 2019·Arquivos de neuro-psiquiatria·Eduardo Fernandes BondanRosemari Otton
Nov 7, 2019·Nutritional Neuroscience·Vittorio Emanuele BianchiRizzi Laura
Sep 27, 2020·Molecular Nutrition & Food Research·Bianca F LeonardiAline R Zimmer
Jan 21, 2021·Nutrients·Kyoko HasebeMargaret J Morris
Jan 29, 2021·Journal of Neuroendocrinology·Hugo MartinXavier Fioramonti
Mar 13, 2021·Eating and Weight Disorders : EWD·Medine TürkoğluSaltuk Buğrahan Ceyhun
Feb 24, 2021·The British Journal of Nutrition·Yinji LiangChenli Lin
May 23, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ying-Yiu LamYun-Wen Chen
Dec 28, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sheng-Feng TsaiYu-Min Kuo

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