High-fat emulsion-induced rat model of nonalcoholic steatohepatitis

Life Sciences
Yuhong ZouYuanyuan Wang

Abstract

Non-alcoholic fatty liver disease (NAFLD) is emerging as a common medical problem. Nonalcoholic steatohepatitis (NASH) is the critical turning point at which NAFLD progresses to more advanced stages such as hepatic fibrosis, cirrhosis and even hepatocellular carcinoma. However, the study of the pathogenic or therapeutic factors involved in NASH has been hampered by the absence of a suitable experimental model. The aim of the present work was to establish a high-fat emulsion-induced rat model of NASH. Male Sprague-Dawley rats were fed a high-fat emulsion via gavage for 6 weeks. Animals were examined for weight gain, serum and hepatic biochemistry, insulin sensitivity, hepatic malondialdehyde (MDA), superoxide dismutase (SOD) and tissue morphology, as well as cytochrome P-450 2E1 (CYP2E1) and peroxisome proliferator-activated receptor alpha (PPARalpha) expression in the liver. The results showed that rats treated with high-fat emulsion became obese, demonstrated abnormal aminotransferase activity, hyperlipoidemia, hyperinsulinemia, hyperglycemia and insulin resistance. The model rats exhibited an increased concentration of serum TNF-alpha, total cholesterol (TC), triglyceride (TG), MDA and reduced SOD levels in the liver. Immunob...Continue Reading

References

Jan 1, 1991·Free Radical Biology & Medicine·H EsterbauerH Zollner
Aug 1, 1986·The American Journal of Clinical Nutrition·S W CorbettR E Keesey
Jul 11, 1983·Life Sciences·J O HillM DiGirolamo
Jan 1, 1994·Annual Review of Nutrition·J K Reddy, G P Mannaerts
Apr 1, 1997·Physiological Reviews·C S Lieber
Apr 18, 1998·Gastroenterology·C P Day, O F James
Apr 30, 1999·Gastroenterology·H Cortez-PintoA M Diehl
Jul 8, 1999·Journal of Internal Medicine·G S Hotamisligil
Jul 22, 1999·The New England Journal of Medicine·P R Shepherd, B B Kahn
Sep 17, 1999·Journal of Hepatology·S H CaldwellW D Parker
Oct 26, 1999·Endocrine Reviews·B Desvergne, W Wahli
Apr 20, 2000·The Journal of Clinical Investigation·I A LeclercqG R Robertson
Jun 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D G FongA L Buchman
Jul 27, 2000·American Journal of Physiology. Endocrinology and Metabolism·J A HarroldG Williams
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jul 27, 2001·Diabetes·G MarchesiniN Melchionda
Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·G RobertsonG C Farrell
Nov 14, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·J K Reddy
Dec 26, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anna Mae Diehl
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shivakumar ChitturiJacob George
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
May 23, 2002·Gastroenterology·Jeanne M ClarkAnna Mae Diehl
Jun 25, 2002·Annals of the New York Academy of Sciences·Virginie BocherBart Staels
Oct 31, 2002·Best Practice & Research. Clinical Gastroenterology·Ayman Koteish, Anna Mae Diehl
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naga ChalasaniDavid W Crabb
Apr 16, 2003·Kidney International. Supplement·Carmine ZoccaliGiovanni Tripepi
Sep 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mercedes Pérez-CarrerasJosé A Solis-Herruzo
Oct 11, 2003·Journal of Gastroenterology and Hepatology·Richard KirschPauline de la M Hall
Feb 27, 2004·The American Journal of Clinical Nutrition·Amin A Nanji
Feb 27, 2004·The American Journal of Clinical Nutrition·Charles S LieberLeonore M DeCarli
May 29, 2004·The Journal of Biological Chemistry·Varman T SamuelGerald I Shulman
Aug 28, 2004·Clinics in Liver Disease·Amin A Nanji
Dec 14, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yona AvniRafael Bruck
Jun 22, 2005·World Journal of Gastroenterology : WJG·Jing AiBao-Feng Yang
Sep 1, 2005·Alcoholism, Clinical and Experimental Research·Qiang WanJiajun Zhao
Sep 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qing-Gao DengHidekazu Tsukamoto

❮ Previous
Next ❯

Citations

Apr 2, 2011·Cell Biology and Toxicology·Aparajita Dey, S Mathan Kumar
May 22, 2009·Digestive Diseases and Sciences·Zheng-Jie XuGuo-Liang Wang
Dec 2, 2010·Nature Reviews. Gastroenterology & Hepatology·Lionel Hebbard, Jacob George
Aug 30, 2008·Journal of Gastroenterology and Hepatology·Claire Z Larter, Matthew M Yeh
Jul 3, 2010·Journal of Gastroenterology and Hepatology·Elango KathirvelTimothy R Morgan
Jun 9, 2011·Journal of Gastroenterology and Hepatology·Otto KučeraZuzana Cervinková
Aug 13, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael CharltonGregory Gores
Sep 11, 2008·BMC Gastroenterology·Luis BujandaJuan I Arenas
Feb 23, 2007·Nutrition & Metabolism·Caroline RomestaingBrigitte Sibille
May 5, 2011·Nutrition & Metabolism·Mehmet TuzcuKazim Sahin
May 27, 2008·International Archives of Medicine·Shanmugam SivabalanVenugopal P Menon
Aug 14, 2008·World Journal of Gastroenterology : WJG·Man-Jie ZhuZheng Zhao
Jun 2, 2012·World Journal of Gastroenterology : WJG·Yoshihisa TakahashiToshio Fukusato
Sep 25, 2012·World Journal of Gastroenterology : WJG·Wei-Hong GongXiao-Lu Cao
Jun 3, 2014·BMC Gastroenterology·Tarak K ChhedaVenkataranganna V Marikunte
Jan 10, 2012·Nutrition Reviews·Christopher Masterjohn, Richard S Bruno
Nov 7, 2009·Scandinavian Journal of Gastroenterology·Ying-Bin Hu, Xin-Yu Liu
Jul 5, 2011·Biochimica Et Biophysica Acta·Guor Mour HerWan-Yu Pai
Jun 15, 2011·Clinics and Research in Hepatology and Gastroenterology·J AubertB Fromenty
Feb 2, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Saroj NepalDharamvir Singh Arya
Apr 27, 2010·Biochimica Et Biophysica Acta·Yun-Sheng ShiehGuor Mour Her
Apr 24, 2008·The Journal of Nutritional Biochemistry·Christopher L Gentile, Michael J Pagliassotti
Aug 11, 2007·Surgery·Abhishek MathurHenry A Pitt
Dec 3, 2015·Digestive Diseases and Sciences·Samar H IbrahimGregory J Gores
May 15, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Xiang-Qun DengNing-Xu Li
May 9, 2013·Molecular Nutrition & Food Research·Inês Correia-SáMaria A Vieira-Coelho
Mar 16, 2011·The Journal of Pharmacy and Pharmacology·Taotao MaWenjian Tang
Jul 4, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Michael WeissMichael S Roberts
Mar 18, 2011·International Journal of Experimental Pathology·Otto KučeraZuzana Cervinková
Jan 28, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Priya HandaKris V Kowdley

❮ Previous
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