High-fat enteral nutrition reduces endotoxin, tumor necrosis factor-alpha and gut permeability in bile duct-ligated rats subjected to hemorrhagic shock

Journal of Hepatology
Misha D LuyerJan Willem M Greve

Abstract

Cholestatic patients are prone to septic complications after major surgery due to an increased susceptibility to endotoxin and hypotension. High-fat enteral nutrition reduces endotoxin after hemorrhagic shock. However, it is unknown whether this nutritional intervention is protective in biliary obstruction. We investigated the effect of high-fat enteral nutrition on endotoxin, tumor necrosis factor-alpha (TNF-alpha) and intestinal permeability in cholestatic rats subjected to hemorrhagic shock. Bile duct-ligated (BDL) rats were fasted or fed with low-fat or high-fat enteral nutrition before hemorrhagic shock. Blood and tissue samples were taken after 90 min. Plasma endotoxin decreased after hemorrhagic shock in BDL-rats fed with high-fat nutrition compared to fasted (P<0.01) and low-fat treated rats (P<0.05). Additionally, circulating TNF-alpha was reduced in BDL-rats pretreated with high-fat nutrition compared to fasted rats (P<0.01). The increased intestinal permeability to macromolecules was reduced by high-fat enteral nutrition, whereas bacterial translocation did not significantly change. Simultaneously, tight junction distribution in ileum and colon was disrupted in non-treated BDL-rats but remained unchanged in high-fat ...Continue Reading

References

Nov 1, 1991·The Journal of Surgical Research·E B EichbaumJ H Rapp
Jan 1, 1990·American Journal of Surgery·E A DeitchR D Specian
Oct 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J W GreveW A Buurman
Jan 1, 1987·Advances in Experimental Medicine and Biology·E A CarterW A Walker
Mar 1, 1993·The Journal of Clinical Investigation·H W HarrisJ H Rapp
Apr 1, 1996·The Journal of Surgical Research·J V ReynoldsW A Tanner
Apr 16, 1998·Gut·W D ClementsB J Rowlands
Dec 29, 1998·Scandinavian Journal of Gastroenterology·N E OsmanB Karlsson
Jan 23, 1999·The New England Journal of Medicine·A P Wheeler, G R Bernard
Jul 3, 1999·The New England Journal of Medicine·F L Luan
Dec 2, 1999·Atherosclerosis·M M Hussain
May 17, 2001·The European Journal of Surgery = Acta Chirurgica·G GoldmanJ M Klausner
May 23, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·M J Engle, D H Alpers
Oct 5, 2001·Annals of Nutrition & Metabolism·S R De VrieseA B Christophe
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anita C E VreugdenhilWim A Buurman
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vicente Lorenzo-ZúñigaMiquel Angel Gassull

❮ Previous
Next ❯

Citations

Oct 12, 2005·The Journal of Experimental Medicine·Misha D LuyerWim A Buurman
Aug 2, 2007·Critical Care Medicine·Misha LuyerWim Buurman
Oct 25, 2008·Annals of Surgery·Jacco-Juri de HaanJan-Willem M Greve
May 24, 2005·Infection and Immunity·Misha D LuyerJan Willem M Greve
May 3, 2006·Journal of the American Veterinary Medical Association·Nicole J BuoteCynthia R L Webster
Oct 26, 2011·World Journal of Gastroenterology : WJG·Misha D P LuyerWim Buurman
Nov 2, 2007·Journal of the American College of Surgeons·Stephen F Lowry
Oct 30, 2008·Journal of Lipid Research·Carl Grunfeld, Kenneth R Feingold
Dec 17, 2008·Journal of Hepatology·Misha D P LuyerJan Willem M Greve

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.