High-fat hyperphagia in neurotrophin-4 deficient mice reveals potential role of vagal intestinal sensory innervation in long-term controls of food intake

Neuroscience Letters
Mardi S Byerly, Edward A Fox

Abstract

Neurotrophin-4 (NT-4) deficient mice exhibit substantial loss of intestinal vagal afferent innervation and short-term deficits in feeding behavior, suggesting reduced satiation. However, they do not show long-term changes in feeding or body weight because of compensatory behaviors. The present study examined whether high-fat hyperphagia induction would overcome compensation and reveal long-term effects associated with the reduced vagal sensory innervation of NT-4 mutants. First, modifications of a feeding schedule previously developed in rats were examined in wild-type mice to identify the regimen most effective at producing hyperphagia. The most successful schedule, which was run for 26 days, included access to a 43%-fat diet and pelleted chow every other day and access to only powdered chow on the alternate days. On high-fat access days mice consumed 25% more calories than mice with continuous daily access to the same high-fat diet and pelleted chow. This feeding regimen also induced hyperphagia in NT-4 deficient mice and their wild-type controls: on high-fat exposure days mutants consumed 35% more calories relative to continuous-access mutants, and wild types ate 25% more than continuous-access wild types. Moreover, on high-...Continue Reading

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Citations

Jun 22, 2012·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Edward A Fox
Jun 19, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicholas T BelloTimothy H Moran
Mar 23, 2012·Digestive Diseases and Sciences·Edward A Fox
Mar 17, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicholas T Bello, Timothy H Moran
Feb 17, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kaitlyn E Gilland, Edward A Fox

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