High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development

Cancer Research
Dong LinYuzhuo Wang

Abstract

Standardized and reproducible preclinical models that recapitulate the dynamics of prostate cancer are urgently needed. We established a bank of transplantable patient-derived prostate cancer xenografts that capture the biologic and molecular heterogeneity currently confounding prognostication and therapy development. Xenografts preserved the histopathology, genome architecture, and global gene expression of donor tumors. Moreover, their aggressiveness matched patient observations, and their response to androgen withdrawal correlated with tumor subtype. The panel includes the first xenografts generated from needle biopsy tissue obtained at diagnosis. This advance was exploited to generate independent xenografts from different sites of a primary site, enabling functional dissection of tumor heterogeneity. Prolonged exposure of adenocarcinoma xenografts to androgen withdrawal led to castration-resistant prostate cancer, including the first-in-field model of complete transdifferentiation into lethal neuroendocrine prostate cancer. Further analysis of this model supports the hypothesis that neuroendocrine prostate cancer can evolve directly from adenocarcinoma via an adaptive response and yielded a set of genes potentially involved...Continue Reading

References

Jan 1, 1976·International Review of Cytology·G R Cunha
Nov 24, 1999·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·J R TunsteadP J Hornsby
Oct 29, 2005·Science·Scott A TomlinsArul M Chinnaiyan
Feb 8, 2006·Genome Research·Stanislav VolikColin Collins
Aug 18, 2006·Nature Reviews. Drug Discovery·Norman E Sharpless, Ronald A Depinho
Nov 1, 2006·Prostate Cancer and Prostatic Diseases·E C NelsonC P Evans
Jan 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph A DiMasi, Henry G Grabowski
Feb 3, 2007·Seminars in Oncology·Jeffrey S PalmgrenMark R Wakefield
May 29, 2007·The American Journal of Surgical Pathology·Sven PernerMark A Rubin
Mar 28, 2008·Genome Biology·Benjamin J RaphaelColin C Collins
Jun 4, 2008·Cancer Research·Dong LinYu-Zhuo Wang
Nov 14, 2008·Clinical Pharmacology and Therapeutics·B Rubio-Viqueira, M Hidalgo
Jan 1, 2009·Journal of the National Cancer Institute·Ken Garber
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Dec 8, 2009·Cancer Cell·Gerhardt AttardJohann S de Bono
Feb 20, 2010·The American Journal of Pathology·Carmen PrioloMassimo Loda
Feb 25, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xin DongYuzhuo Wang
May 18, 2010·The American Journal of Pathology·Hongjuan ZhaoDonna M Peehl
Jun 29, 2010·Cancer Cell·Barry S TaylorWilliam L Gerald
Nov 26, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ursula KortmannC Blake Gilks
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Feb 11, 2011·Nature·Michael F BergerLevi A Garraway
Feb 22, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tamara L LotanGeorge J Netto
Apr 19, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sean R WilliamsonLiang Cheng
Aug 24, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark A RubinArul M Chinnaiyan
Oct 8, 2011·PloS One·Akira WatahikiYuzhuo Wang
Dec 14, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vassiliki TzelepiAna M Aparicio
Dec 14, 2011·Cancer Research·Terence W FriedlanderPamela L Paris
May 23, 2012·Nature Genetics·Christopher E BarbieriLevi A Garraway
Jun 23, 2012·Nature·Catherine S GrassoScott A Tomlins
Aug 17, 2012·The New England Journal of Medicine·Howard I ScherUNKNOWN AFFIRM Investigators
Apr 6, 2013·Nature Protocols·Mitchell G LawrenceGail P Risbridger
May 31, 2013·Science Translational Medicine·Roxanne ToivanenGail P Risbridger

❮ Previous
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Citations

Mar 5, 2014·Asian Journal of Andrology·Dong LinYuzhuo Wang
Aug 15, 2014·Proceedings of the National Academy of Sciences of the United States of America·Justin M Drake, Jiaoti Huang
Sep 23, 2014·Nature Cell Biology·Chee Wai ChuaMichael M Shen
Feb 9, 2016·Nature Medicine·Himisha BeltranFrancesca Demichelis
Jun 3, 2014·Biology·Carrie J LovittVicky M Avery
Nov 5, 2014·Expert Opinion on Drug Discovery·Richard C LauerWadih Arap
Jun 2, 2015·Expert Opinion on Drug Discovery·Kenneth C Valkenburg, Kenneth J Pienta
Feb 16, 2016·Clinical Epigenetics·Pier-Luc ClermontCheryl D Helgason
Oct 12, 2014·Advanced Drug Delivery Reviews·Stephen Yiu Chuen ChoiYuzhuo Wang
Aug 27, 2014·Genome Biology·Alexander W WyattColin C Collins
Sep 25, 2014·Cell Communication and Signaling : CCS·Myles C HodgsonIrina U Agoulnik
Aug 21, 2014·International Journal of Cancer. Journal International Du Cancer·Ning XieXuesen Dong
Mar 10, 2015·Molecular Cancer·Abhijit ParoliaCheryl D Helgason
Apr 3, 2016·Journal of Experimental & Clinical Cancer Research : CR·Hongtuan ZhangYong Xu
Aug 25, 2015·Seminars in Cancer Biology·Frédéric R SanterRhiannon V McNeill
Jun 16, 2015·The Prostate·Matthias SaarMichael D Menger
Aug 4, 2015·Cell Reports·Shusuke AkamatsuColin C Collins
May 20, 2015·Cancer Treatment Reviews·Maria KatsogiannouPalma Rocchi
May 3, 2015·Endocrine-related Cancer·Jennifer L BishopAmina Zoubeidi
Apr 11, 2015·Clinical Epigenetics·Pier-Luc ClermontCheryl D Helgason
Nov 9, 2015·Differentiation; Research in Biological Diversity·Yuzhuo WangJun Pang
Oct 29, 2014·Endocrine-related Cancer·Lisa D Berman-Booty, Karen E Knudsen
May 15, 2016·Hormones & Cancer·Gail P Risbridger, Renea A Taylor
Jun 14, 2016·BioMed Research International·Domenica ReaClaudio Arra
Sep 27, 2016·Expert Review of Molecular Diagnostics·Carlo BuonerbaGuru Sonpavde
Nov 12, 2016·Nature Reviews. Cancer·Jinjun ShiOmid C Farokhzad
Nov 2, 2016·Endocrine-related Cancer·Isabel CoutinhoLuke A Selth
Nov 23, 2016·Nature Reviews. Clinical Oncology·Guilhem RoubaudDavid J Mulholland
Mar 2, 2017·Nature Reviews. Urology·Takahiro InoueOsamu Ogawa
Apr 1, 2017·Current Oncology Reports·Panagiotis J VlachostergiosHimisha Beltran
Jun 7, 2017·Nature Medicine·David S RickmanMark A Rubin
Feb 21, 2018·Nature Reviews. Urology·Alastair H DaviesAmina Zoubeidi
Feb 6, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Shusuke AkamatsuMartin E Gleave

❮ Previous
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