High-field solid-state (67)Zn NMR spectroscopy of several zinc-amino acid complexes

The Journal of Physical Chemistry. a
Kamal H Mroué, William P Power

Abstract

We report the results of our solid-state (67)Zn NMR study of the various zinc sites in four zinc-amino acid coordination complexes: bis(glycinato)zinc(II) monohydrate; bis(l-alaninato)zinc(II); bis(l-histidinato)zinc(II) dihydrate; and sodium bis(l-cysteinato)zincate(II) hexahydrate; as well as a related complex, bis(imidazole)zinc(II) chloride. We demonstrate the advantages of using high (21.1 T) applied magnetic fields for detecting (67)Zn directly at ambient temperatures using the quadrupolar Carr-Purcell Meiboom-Gill (QCPMG) pulse sequence. The stepped-frequency technique was employed in cases where the central-transition (CT) (67)Zn NMR spectra were too broad to be uniformly excited. The parameters of the anisotropic zinc tensors were extracted by iterative simulations of the experimental spectra. In all cases, the quadrupolar interaction is found to dominate the central-transition (67)Zn NMR spectra; no convincing effects from chemical shift anisotropy (CSA) on the NMR spectra of the five complexes could be reliably detected at this field strength. Analyses of the experimental NMR spectra reveal that the (67)Zn quadrupolar coupling constants (C(Q)) range from 7.05 to 26.4 MHz, the isotropic chemical shifts (delta(iso)) ra...Continue Reading

References

Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B L ValleeD S Auld
Dec 10, 1966·Acta Crystallographica·B K Lundberg
Oct 1, 1995·Protein Science : a Publication of the Protein Society·D R HollandB W Matthews
Jan 1, 1997·Annual Review of Biophysics and Biomolecular Structure·J M Berg, H A Godwin
Mar 19, 1999·Protein Science : a Publication of the Protein Society·I L AlbertsS J Wodak
May 10, 2000·The Journal of Nutrition·K A McCallC A Fierke
Nov 28, 2000·Acta Crystallographica. Section D, Biological Crystallography·G D SmithR H Blessing
Jan 17, 2002·Journal of the American Chemical Society·Andrew S LiptonPaul D Ellis
Nov 7, 1996·Chemical Reviews·William N. Lipscomb, Norbert Sträter
Apr 9, 2004·Journal of the American Chemical Society·Andrew S LiptonPaul D Ellis
Apr 15, 2004·Journal of Magnetic Resonance·Andrew S LiptonPaul D Ellis
Feb 24, 2005·Journal of the American Chemical Society·Yong ZhangEric Oldfield
Jul 25, 2006·Chemical Society Reviews·Sharon E Ashbrook, Mark E Smith
Dec 19, 2006·Journal of Magnetic Resonance·Peter L Gor'kovWilliam W Brey
Jun 28, 2007·Journal of the American Chemical Society·Andrew S Lipton, Paul D Ellis
Nov 27, 2007·The Journal of Chemical Physics·Rangeet Bhattacharyya, Lucio Frydman
Apr 16, 2008·Journal of the American Chemical Society·Andrew S LiptonPaul D Ellis
Sep 3, 2008·Journal of the American Chemical Society·Andrew S LiptonPaul D Ellis
Dec 23, 2008·Chemical Communications : Chem Comm·Andre SutrisnoYining Huang

❮ Previous
Next ❯

Citations

Nov 5, 2013·Solid State Nuclear Magnetic Resonance·Luke A O'Dell
Aug 17, 2018·Magnetic Resonance in Chemistry : MRC·César LeroyDavid L Bryce
Dec 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·N KanwalI Abrahams
Oct 5, 2013·Journal of the American Chemical Society·Simon J HibbleAlex C Hannon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.