High first-trimester maternal blood cystatin C levels despite normal serum creatinine predict pre-eclampsia in singleton pregnancies

Scandinavian Journal of Clinical and Laboratory Investigation
Martin RischLorenz Risch

Abstract

Early biochemical identification of women at high risk for the development of pre-eclampsia (PE) is still unsatisfactory. Renal markers measured during the first trimester were analysed to predict later occurrence of PE. A nested case-control study was conducted within the prospective predictive markers for the diagnosis of preeclampsia study. Pregnant women were included at the end of the first trimester and followed up until birth. Controls were matched to PE cases. Renal markers [i.e. creatinine, cystatin C (CysC), β2 microglobulin (B2M), β-trace protein (BTP), glomerular filtration rate estimations (eGFR) of the aforementioned markers, uric acid (UA), urea, and serum uromodulin (sUMOD)] were compared to placental growth factor (PlGF), a marker known to predict PE later in pregnancy. Reference intervals were determined for the different markers. In the 183 women (PE, n = 39; controls, n = 144), CysC, the CysC/PlGF ratio (p < .01) and UA were higher, whereas the eGFRCysC/eGFRCrea ratio (a marker of glomerular endothelial integrity and shrunken pore syndrome) and PlGF were lower in women who developed PE (p < .05 for all). Compromised filtration of the larger molecule CysC together with a normal creatinine, in a subset of PE c...Continue Reading

References

Apr 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·M A Laurenzi, H Link
Jun 5, 1993·Lancet·J M Roberts, C W Redman
Oct 21, 2000·Advances in Clinical Chemistry·A O Grubb
Nov 21, 2000·Obstetrics and Gynecology·R A OdegårdR Austgulen
Jan 5, 2002·Scandinavian Journal of Clinical and Laboratory Investigation·H StrevensA Grubb
Aug 12, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Jun ZhangAnn Trumble
Dec 2, 2004·Obstetrics and Gynecology·Agustin Conde-AgudeloMarshall Lindheimer
Jan 22, 2005·Seminars in Nephrology·Chun LamS Ananth Karumanchi
Jul 27, 2007·Acta Obstetricia Et Gynecologica Scandinavica·K KristensenA Grubb
Aug 19, 2007·American Journal of Physiology. Renal Physiology·Catarina RippeBengt Rippe
Nov 3, 2007·BMJ : British Medical Journal·Leanne BellamyDavid J Williams
Jan 17, 2008·Renal Failure·Nora FranceschiniMichelle A Williams
Jan 3, 2009·Kidney International·Lesley A StevensAndrew S Levey
Mar 7, 2009·Stroke; a Journal of Cerebral Circulation·Eero KajantieDavid J P Barker
Jan 1, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Ulf NymanAnders Grubb
Jan 1, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·K KristensenD Wide-Swensson
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
May 14, 2009·Reproductive Sciences·Basky ThilaganathanJoanna Sheldon
May 27, 2010·Obstetrics and Gynecology·Basky ThilaganathanAris T Papageorghiou
Nov 3, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Anders GrubbUNKNOWN IFCC Working Group on Standardisation of Cystatin C (WG-SCC)
Jan 22, 2011·American Journal of Hypertension·S Katherine LaughonRobin E Gandley
Jul 12, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Aleksandra Novakov MikicZoran Stosic
Aug 31, 2011·Hypertension·Gianni BellomoPier Luca Narducci
Jan 28, 2012·Seminars in Perinatology·Labib Ghulmiyyah, Baha Sibai
Jul 6, 2012·The New England Journal of Medicine·Lesley A InkerUNKNOWN CKD-EPI Investigators
Aug 17, 2012·Expert Review of Cardiovascular Therapy·Gianni Bellomo
Jul 11, 2013·BMJ : British Medical Journal·Kristin Melheim StrandTorstein Vik
Aug 20, 2014·Obstetrics and Gynecology International·Leona C Poon, Kypros H Nicolaides
Dec 5, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·G S MooreK D Heyborne
Apr 3, 2015·The Journal of Clinical Hypertension·Ting-ting XuXiao-dong Wang
Apr 29, 2015·Scandinavian Journal of Clinical and Laboratory Investigation·Anders GrubbAnders Christensson
Aug 22, 2015·Cold Spring Harbor Perspectives in Medicine·Tammy HodS Ananth Karumanchi
Sep 8, 2015·Lancet·Ben W J MolG Justus Hofmeyr
Sep 13, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lesley A InkerAndrew S Levey
Dec 20, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Anthony J Bleyer, Stanislav Kmoch
Jan 7, 2016·The New England Journal of Medicine·Harald ZeislerStefan Verlohren
Mar 5, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hans PottelPierre Delanaye
Mar 10, 2016·Obstetrics and Gynecology·Katherine A AhrensEnrique F Schisterman

❮ Previous
Next ❯

Citations

Jan 9, 2019·Kidney Research and Clinical Practice·Krittanont WattanavaekinChatchai Kreepala
Feb 21, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Araceli Jarquin CamposMartin Risch
Nov 23, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Emil den BakkerArend Bökenkamp
May 26, 2020·Expert Review of Molecular Diagnostics·Stefanie W BenoitPrasad Devarajan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Sherif SalehJoseph Aquilina
The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Lai Wa LawTak Yeung Leung
© 2022 Meta ULC. All rights reserved