High-Fluence Light-Emitting Diode-Generated Red Light Modulates the Transforming Growth Factor-Beta Pathway in Human Skin Fibroblasts

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Andrew Mamalis, Jared Jagdeo

Abstract

Skin fibrosis is a significant medical problem with limited available treatment modalities. The key cellular characteristics include increased fibroblast proliferation, collagen production, and transforming growth factor-beta (TGF-B)/SMAD pathway signaling. The authors have previously shown that high-fluence light-emitting diode red light (HF-LED-RL) decreases cellular proliferation and collagen production. Herein, the authors investigate the ability of HF-LED-RL to modulate the TGF-B/SMAD pathway. Normal human dermal fibroblasts were cultured and irradiated with a commercially available hand-held LED array. After irradiation, cell lysates were collected and levels of pSMAD2, TGF-Beta 1, and TGF-Beta I receptor were measured using Western blot. High-fluence light-emitting diode red light decreased TGF-Beta 1 ligand (TGF-B1) levels after irradiation. 320 J/cm HF-LED-RL resulted in 59% TGF-B1 and 640 J/cm HF-LED-RL resulted in 54% TGF-B1, relative to controls. 640 J/cm HF-LED-RL resulted in 62% pSMAD2 0 hours after irradiation, 65% pSMAD2 2 hours after irradiation, and 95% 4 hours after irradiation, compared with matched controls. High-fluence light-emitting diode red light resulted in no significant difference in transforming gr...Continue Reading

References

Aug 23, 2002·The Journal of Investigative Dermatology·TaiHao QuanGary J Fisher
Jan 11, 2003·BMJ : British Medical Journal·A BayatM W J Ferguson
Feb 10, 2012·The Journal of Investigative Dermatology·Frank LiebelMichael D Southall
Jul 10, 2012·Nature Medicine·Thomas A Wynn, Thirumalai R Ramalingam
Apr 18, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Hadar Lev-TovJared Jagdeo
Sep 17, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·A D MamalisJ R Jagdeo
Oct 10, 2013·Plastic and Reconstructive Surgery·Angeline F LimMichael T Longaker
Nov 18, 2014·Current Pathobiology Reports·Anjali ShroffJared Jagdeo
Dec 9, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Andrew Mamalis, Jared Jagdeo
May 14, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Andrew MamalisJared Jagdeo
May 18, 2016·Current Dermatology Reports·Andrew MamalisJared Jagdeo
Dec 28, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Andrew Mamalis, Jared Jagdeo

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