PMID: 8968025Dec 1, 1996Paper

High fluoride intakes cause osteomalacia and diminished bone strength in rats with renal deficiency

Bone
C H TurnerA J Dunipace

Abstract

Renal insufficiency is known to increase plasma fluoride levels, which may increase the risk of fluorosis and osteomalacia. The purpose of this study was to determine the effects of fluoride on skeletal fragility and mineralization in renal-deficient animals. We evaluated the skeleton of rats with surgically induced renal deficiency (4/5 nephrectomy) that were chronically exposed to fluoridated water at concentrations of 0, 5, 15, and 50 ppm for a period of 6 months. The chosen fluoride doses caused plasma fluoride levels equivalent to those in humans consuming fluoridated water levels of 0, 1, 3, and 10 ppm, respectively. Animals with renal deficiency drank about 60% more water and excreted 85% more urine than control animals. Glomerular filtration rate (GFR) was decreased 68% and plasma BUN was increased fourfold in rats with renal deficiency. Plasma fluoride was strongly correlated with 1/GFR and was greatly increased by renal deficiency in all animals consuming fluoridated water. There was a strong positive, nonlinear relationship between plasma fluoride and bone fluoride levels, suggesting nonlinear binding characteristics of fluoride to bone. The amount of unmineralized osteoid in the vertebral bone was related to the pla...Continue Reading

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Citations

Jan 1, 2006·Environmental Health and Preventive Medicine·Kan UsudaKazuo Nakasuji
Dec 4, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Patrick Ammann
Jun 3, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A NazarianB D Snyder
Feb 11, 2010·Journal of Bone and Mineral Metabolism·Muhammad Zulfadli MehatIma Nirwana Soelaiman
Aug 4, 2010·Cell Biology and Toxicology·Euridice PradoAriane Berdal
Mar 14, 2009·Journal of Materials Science. Materials in Medicine·O ClarkinM R Towler
Apr 21, 2010·Biological Trace Element Research·Maela LupoAlfredo Rigalli
Mar 26, 2005·Seminars in Nephrology·Richard A Ward
Sep 21, 2013·Toxicology Letters·Ekambaram PerumalLakshmikanthan Panneerselvam
Apr 27, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·A NicolayJ P Reynier
Jan 14, 2000·Kidney International. Supplement·M M CouttenyeM E De Broe
May 13, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·W E CabreraP C D'Haese
Aug 11, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Jean-Yves ReginsterBruno Flamion
May 19, 2009·Journal of Biomechanics·Ara NazarianBrian D Snyder
Sep 20, 2005·Micron : the International Research and Review Journal for Microscopy·Jeffry S NymanXiaodu Wang
Feb 28, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Martine E Cohen-SolalMarie-Christine de Vernejoul
Feb 8, 2019·Indian Journal of Clinical Biochemistry : IJCB·Joseph Dian BonduJude Joseph Fleming
Nov 7, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R Vieth
Aug 30, 2019·Journal of Agricultural and Food Chemistry·Jinming WangJundong Wang

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