High-flux hemodialysis postpones clinical manifestation of dialysis-related amyloidosis

American Journal of Nephrology
C KüchleH Schiffl

Abstract

Amyloidosis due to the retention of beta 2-microglobulin (beta 2-MG) is a frequent complication of hemodialysis (HD). Significant amounts of beta 2-MG can be removed from the body by highly permeable HD membranes, whereas conventional low-flux membranes are impermeable for the molecule. In a prospective and controlled study we investigated whether high-flux HD could delay the onset of dialysis-related amyloidosis (DRA). Twenty patients treated with cuprophane low-flux HD membranes were matched for age and previous time on HD either to continue their HD regimen or to receive HD treatment with high-flux polysulfone membranes. For 6 years each patient was examined for manifestations of DRA once a year or upon individual needs, additionally, serum beta 2-MG levels were monitored. After 6 years of follow-up no clinical signs of DRA were found in any of the patients dialyzed with high-flux polysulfone membranes, whereas 8/10 of the conventionally dialyzed patients had CTS and/or osteoarticular lesions. Serum levels of beta 2-MG were significantly reduced in patients treated with high-flux polysulfone membranes.

Citations

Jun 8, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Yuichi SatoTatsuya Chikaraishi
Oct 28, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Muriel P C Grooteman, Menso J Nubé
May 10, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tadakazu OokoshiHironobu Naiki
Dec 20, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shigeru OtsuboTakashi Akiba
Apr 24, 2009·Seminars in Dialysis·Arun V KrishnanMatthew C Kiernan
Aug 28, 2009·Seminars in Dialysis·Tilman B Drüeke, Ziad A Massy
Aug 26, 1998·Annals of the Rheumatic Diseases·S P McDonaldA P Disney
Oct 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Enric VilarKen Farrington
Nov 4, 2000·Radiology·J P SlavotinekM R Sage
Jan 1, 2003·Hemodialysis International·Raymond C VanholderRita V De Smet
May 2, 2002·Kidney International. Supplement·Francesco LocatelliSalvatore Di Filippo
Jun 18, 2004·Kidney International·Mark UnruhUNKNOWN HEMO Study Group
May 16, 2013·Nephrology·Peter G KerrUNKNOWN Caring for Australasians with Renal Impairment
Jul 25, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Junichi HoshinoYoshiharu Tsubakihara
Jun 8, 2015·La Presse médicale·Etienne Meriglier, Olivier Fritz
Aug 5, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·J Kay, T Bardin
Apr 2, 2014·BioMed Research International·Giuseppe CoppolinoGiorgio Fuiano
Jun 5, 2002·Plastic and Reconstructive Surgery·Huseyin BormanSeyhan Sozay
Dec 18, 2003·Artificial Organs·S MandolfoE Imbasciati
Mar 30, 2004·Artificial Organs·Tony Bouré, Raymond Vanholder
Jan 12, 2013·Blood Purification·Helmut Schiffl
May 21, 2015·The Cochrane Database of Systematic Reviews·Ionut NistorGiovanni F M Strippoli
Dec 30, 2006·Muscle & Nerve·Arun V Krishnan, Matthew C Kiernan
Aug 5, 2005·Plastic and Reconstructive Surgery·Jamal Gousheh, Afshin Iranpour
Jan 31, 2006·Hemodialysis International·Pietro PozzoniFrancesco Locatelli
Aug 3, 2007·Archives of Orthopaedic and Trauma Surgery·Hamid Namazi, Zahra Majd
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Suetonia C PalmerGiovanni F M Strippoli
Sep 9, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H OkadaH Suzuki
Jun 1, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H SchifflE Mangel
Sep 27, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M J Nubé, M P Grooteman
Jun 14, 2018·Seminars in Dialysis·Shuzo Kaneko, Kunihiro Yamagata
Mar 27, 2001·Seminars in Dialysis·M I Jaradat, S M Moe
Mar 27, 2001·Seminars in Dialysis·J B Copley, J S Lindberg
Jul 25, 2000·Clinical Orthopaedics and Related Research·S J KimE S Kang
Dec 19, 2002·The International Journal of Artificial Organs·J I Merello GodinoC Ronco
Apr 1, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·V DavankovE Yousha
Nov 30, 2000·Journal of the American Society of Nephrology : JASN·Richard A WardWalter Samtleben
Aug 5, 2021·Clinical Kidney Journal·Emilio Sánchez-ÁlvarezUNKNOWN COSMOS group
Aug 21, 2021·Clinical and Experimental Nephrology·Masaki HatanoYoshifumi Ubara
Sep 18, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J HartmannH Schiffl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.