PMID: 11911099Mar 26, 2002Paper

High frame rate Doppler echocardiography in the rat: an evaluation of the method

European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology
R BjornerheimO A Smiseth

Abstract

In small animal models, two-dimensional (2D) and Doppler echocardiography should provide more information than M-mode, especially in animals with infarcted and distorted left ventricles, but has been limited by low frame rates and poor near field resolution. New, high frame rate echo-Doppler equipment with digital processing was tested for accuracy of measurements. Fourteen normal Wistar rats (232-328 g) were examined under halothane anaesthesia. Pulsed Doppler recordings from both left ventricular outflow tract(LVOT) and right ventricular outflow tract (RVOT) cor-responded well with simultaneous ultrasound transit time measurements of aortic flow (LVOT: v=0.99x+4.8, min R=0.93. Standard error of estimate (SEE)=8.3 ml x min(-1), and RVOT: v=0.97x -4.3. R=0.93. SEE =8.4 ml x min(-1). No systematic differences were observed over a flow range of 20-90 ml x min(-1). Left ventricular (LV) dimensions assessed by 2D parasternal long-axis and short-axis views were equal to M-mode measurements with LV diameter 6.6 + 0.44 mm, anterior wall 1.8 +/- 0.18 mm, and posterior wall 1.5 + 0.56 mm. Mean absolute difference 4.4-8.5%. Intra- and interobserver variability was 4.6 +/- 4.1% and 6.7 +/- 7.0% for Doppler measurements, and 4.3 +/- 3.8% a...Continue Reading

Citations

Dec 1, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Elizabeth PurssellTerence R S Ozolinš
Sep 24, 2005·Journal of Pharmacological Sciences·Yuji KawaharaSatoshi Takeo
Mar 23, 2005·Circulation·Björn I GustafssonHelge Waldum
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Michel SlamaMichel Andrejak
Mar 22, 2006·European Journal of Heart Failure·Arne YndestadErik Oie
May 15, 2007·Coronary Artery Disease·Gerald H WasmeierUwe Nixdorff
Aug 3, 2002·Hypertension·Michel SlamaEdward D Frohlich
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Mar 26, 2005·Canadian Journal of Physiology and Pharmacology·R SouthworthP B Garlick
Aug 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pierre BonnetVéronique Eder
Nov 10, 2020·Physiological Measurement·Dorota SztechmanAgnieszka Cudnoch-Jędrzejewska

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