High frequencies of F1534C and V1016I kdr mutations and association with pyrethroid resistance in Aedes aegypti from Somgandé (Ouagadougou), Burkina Faso

Tropical Medicine and Health
Aboubacar SombiéAthanase Badolo

Abstract

Resistance to pyrethroid insecticides involving kdr mutations is widespread in Aedes aegypti (L.) (Diptera: Culicidae) and potentially could impact control efforts in endemic countries. Dengue cases had been sporadic in Burkina Faso for over a decade prior to the 2016-2017 outbreak that resulted in 15,074 suspected cases and 36 deaths, mainly in Ouagadougou. These outbreaks highlighted the lack of information on numerous aspects of the biology, behaviour and insecticide status of local dengue vector populations that are fundamental to vector control. We investigated the insecticide resistance profiles and the kdr mutations involved in pyrethroid resistance of Ae. aegypti from Somgandé, a district of Ouagadougou. WHO bioassays revealed that the local Ae. aegypti populations were highly resistant to pyrethroids with mortalities of 15% for permethrin and 37% for deltamethrin. Resistance to carbamates was also detected with mortalities of 55% for propoxur and 90% for bendiocarb, but high mortalities (> 97%) to organophosphates (malathion and fenitrothion) indicated susceptibility. Allele-specific PCR and voltage-gated sodium channel gene sequencing showed a very high frequency (97%) of the F1534C kdr allele whilst the V1016I kdr mu...Continue Reading

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Citations

Jun 25, 2019·PloS One·Tri Baskoro Tunggul Satoto Kuswati
Apr 18, 2020·PLoS Neglected Tropical Diseases·Yinjun FanJeffrey G Scott
May 24, 2019·PLoS Neglected Tropical Diseases·Athanase BadoloDavid Weetman
May 8, 2020·Archives of Insect Biochemistry and Physiology·Mengli ChenKe Dong
Nov 4, 2020·Infectious Diseases of Poverty·Aurelie P YougangCharles S Wondji
May 11, 2021·PLoS Neglected Tropical Diseases·Ndeye Marie SeneMawlouth Diallo

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

R
Genetics package

Related Concepts