High-Frequency (1 kHz) Spinal Cord Stimulation-Is Pulse Shape Crucial for the Efficacy? A Pilot Study

Neuromodulation : Journal of the International Neuromodulation Society
Zhiyang SongB Linderoth

Abstract

Conflicting data regarding the efficacy of high-frequency spinal cord stimulation (HF SCS) has prompted the issue of the possible importance of the shape of the stimulating pulses. The aim of this pilot study was to compare HF SCS applied with monophasic and biphasic pulses of two different durations with conventional SCS in a rat model of neuropathic pain. Rats were operated with lesions of sciatic nerve branches according to the spared nerve injury procedure (SNI). Animals, which developed pathological tactile hypersensitivity after surgery, were implanted with four-polar miniature SCS leads. SCS was applied during 60 min with either conventional current parameters (monophasic pulse width [PW]: 200 μsec; 50 Hz and amplitude 80% of the motor threshold [MT]), or with high-frequency SCS (1 kHz) with monophasic or biphasic pulses, the latter with pulse widths of either 24 (12 + 12) or 48 (24 + 24) μsec. The outcomes were examined regarding change of tactile hypersensitivity during the one-hour SCS period and with two tests of thermal sensitivity. Conventional monophasic SCS, as well as HF SCS applied with monophasic PW = 24 μsec or with biphasic PW = 48 (24 + 24) μsec, had similar suppressive effects on tactile hypersensitivity. ...Continue Reading

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Citations

May 7, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Jonathan P MillerBengt Linderoth
Nov 23, 2016·The Clinical Journal of Pain·Xiaoxiao PanLingqing Zeng
Jun 2, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Bengt Linderoth, Robert D Foreman
Nov 23, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Shiying LiRobert D Foreman
Dec 18, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Zhiyong ChenYun Guan
Mar 1, 2019·The Journal of Physiology·Mohamad FallahRadMarom Bikson
May 10, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Ricardo VallejoDavid L Cedeño
Dec 28, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Mark C BicketShihab U Ahmed
Aug 7, 2019·Annals of Biomedical Engineering·Alexander R KentBeth A Winkelstein

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