Abstract
We explored the optimal regime in preventing or treating bone loss, using ovariectomised rodents loaded by mechanical stimuli with rest days during the loading cycle. Eighty-four Sprague-Dawley rats, aged 6 months, were randomly divided into 7 groups after bilateral ovariectomy. Mechanical vibration with 1-day rest (ML1R), with 3-day rest (ML3R), with 5-day rest (ML5R), with 7-day rest (ML7R), daily loading (DL), comparing the ovariectomised group (OVX) with baseline (BCL) measurements. After a recovery of one week, all the rodents were loaded daily by whole body vibration at 35 Hz and 0.25 g for 15 minutes. Eight weeks later, a three-point bending test of the radius and micro-CT scanning of the femoral head were performed after animal sacrifice. Large improvements in biomechanical properties occurred in all the experimental groups for failure load, elastic modulus and deflection, while a significantly enhanced efficacy was detected in ML7R compared with daily loading (p<0.05). In micro-CT scanning, bone volume fraction, trabecular thickness, number and separation were improved by the regime in all experimental groups, while ML7R showed a significant improvement over daily loading (p<0.05). Early bone loss in human subjects may...Continue Reading
References
Oct 1, 1996·The Journal of Bone and Joint Surgery. American Volume·C RubinK McLeod
Apr 1, 1997·Bone·A Odgaard
Nov 18, 1998·Calcified Tissue International·J FliegerG Lyritis
Aug 9, 2001·Nature·C RubinK McLeod
Aug 10, 2001·Drug Discovery Today·C T. RubinY -X. Qin
Jan 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Clinton RubinYi-Xian Qin
Feb 6, 2002·Medicine and Science in Sports and Exercise·Alexander G RoblingCharles H Turner
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alexander G RoblingCharles H Turner
Sep 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sundar SrinivasanTed S Gross
Feb 8, 2003·Annals of Biomedical Engineering·Stefan JudexClinton Rubin
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Clinton RubinKenneth McLeod
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kate WardZulf Mughal
Mar 22, 2005·Bone·L K SaxonC H Turner
Jul 4, 2006·Journal of Biomechanics·Stefan JudexClinton Rubin
Jul 11, 2006·Bone·Liqin XieStefan Judex
Aug 31, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Vicente GilsanzClinton Rubin
Dec 2, 2006·BMC Musculoskeletal Disorders·Narcís GusiAlejo Leal
Oct 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·C T RubinS Judex
Jan 26, 2008·Calcified Tissue International·Jizu ZhiMichael Hadjiargyrou
Feb 9, 2008·Journal of Applied Physiology·Liqin XieStefan Judex
Aug 9, 2008·Endocrinology·Buer SenJanet Rubin
Oct 17, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kwok Sui LeungNing Tang
Jan 24, 2009·Bone·E TanckB Van Rietbergen
Mar 14, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S SehmischE K Stuermer
Sep 23, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Z-M ZhangL-Y Dai
Oct 21, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Poupak Rahmani, Suzanne Morin
Nov 26, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y K LuuC T Rubin
Dec 8, 2009·Bone·Hong-Fei ShiKwok-Sui Leung
Apr 9, 2010·The Journal of Clinical Endocrinology and Metabolism·M NilssonM Lorentzon
Jul 20, 2010·Bone·Karl H WengerJack C Yu
Sep 21, 2010·Bone·Hoyan LamYi-Xian Qin
Sep 25, 2010·Journal of Pediatric Orthopedics·Tishya A L WrenVicente Gilsanz
Nov 6, 2010·Calcified Tissue International·M TezvalE K Stuermer
Dec 7, 2010·Journal of Biomechanics·Buer SenJanet Rubin
Mar 26, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Dick Ho-Kiu ChowWing-Hoi Cheung
May 28, 2011·Acta Physiologica Hungarica·Julia Fedotova, N Ordyan
Citations
Jan 21, 2016·Annals of Biomedical Engineering·Jiazi GaoDong Zhu
Jul 12, 2013·Molecular and Cellular Biochemistry·Yuqiong WuBing Fang
Sep 19, 2019·Acta Cirúrgica Brasileira·Degong MuXizheng Zhang
Jul 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaoqin YuLiang Li
Oct 2, 2014·Molecular Medicine Reports·Yong-Qiang LiangMin Hu
Jul 19, 2018·Science China. Life Sciences·He GongDong Zhu
Mar 19, 2014·PloS One·Rui ZhangYubo Fan
Nov 13, 2014·Calcified Tissue International·Lubomira SlatkovskaAngela M Cheung
Aug 8, 2015·Physics in Medicine and Biology·Zhengyi HuDavid W Holdsworth
Apr 20, 2013·Biomedical Engineering Online·Wan Zong mingZhang Xi zheng
Jan 3, 2014·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Zong-ming WanXi-zheng Zhang
Dec 30, 2016·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Lei TanDong Zhu
Oct 18, 2020·Current Osteoporosis Reports·Sarah E Little-LetsingerMaya Styner
Apr 24, 2021·Aging·Jirui WenLiang Li
May 28, 2021·Cell Biochemistry and Function·Liwei MaoJun Zou