High-frequency and low-magnitude whole body vibration with rest days is more effective in improving skeletal micro-morphology and biomechanical properties in ovariectomised rodents

Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
Renshi MaXizheng Zhang

Abstract

We explored the optimal regime in preventing or treating bone loss, using ovariectomised rodents loaded by mechanical stimuli with rest days during the loading cycle. Eighty-four Sprague-Dawley rats, aged 6 months, were randomly divided into 7 groups after bilateral ovariectomy. Mechanical vibration with 1-day rest (ML1R), with 3-day rest (ML3R), with 5-day rest (ML5R), with 7-day rest (ML7R), daily loading (DL), comparing the ovariectomised group (OVX) with baseline (BCL) measurements. After a recovery of one week, all the rodents were loaded daily by whole body vibration at 35 Hz and 0.25 g for 15 minutes. Eight weeks later, a three-point bending test of the radius and micro-CT scanning of the femoral head were performed after animal sacrifice. Large improvements in biomechanical properties occurred in all the experimental groups for failure load, elastic modulus and deflection, while a significantly enhanced efficacy was detected in ML7R compared with daily loading (p<0.05). In micro-CT scanning, bone volume fraction, trabecular thickness, number and separation were improved by the regime in all experimental groups, while ML7R showed a significant improvement over daily loading (p<0.05). Early bone loss in human subjects may...Continue Reading

References

Oct 1, 1996·The Journal of Bone and Joint Surgery. American Volume·C RubinK McLeod
Aug 10, 2001·Drug Discovery Today·C T. RubinY -X. Qin
Jan 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Clinton RubinYi-Xian Qin
Feb 6, 2002·Medicine and Science in Sports and Exercise·Alexander G RoblingCharles H Turner
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alexander G RoblingCharles H Turner
Sep 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sundar SrinivasanTed S Gross
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Clinton RubinKenneth McLeod
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kate WardZulf Mughal
Aug 31, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Vicente GilsanzClinton Rubin
Oct 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·C T RubinS Judex
Feb 9, 2008·Journal of Applied Physiology·Liqin XieStefan Judex
Oct 17, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kwok Sui LeungNing Tang
Jan 24, 2009·Bone·E TanckB Van Rietbergen
Mar 14, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S SehmischE K Stuermer
Sep 23, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Z-M ZhangL-Y Dai
Oct 21, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Poupak Rahmani, Suzanne Morin
Nov 26, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y K LuuC T Rubin
Apr 9, 2010·The Journal of Clinical Endocrinology and Metabolism·M NilssonM Lorentzon
Jul 20, 2010·Bone·Karl H WengerJack C Yu
Sep 25, 2010·Journal of Pediatric Orthopedics·Tishya A L WrenVicente Gilsanz
Mar 26, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Dick Ho-Kiu ChowWing-Hoi Cheung
May 28, 2011·Acta Physiologica Hungarica·Julia Fedotova, N Ordyan

❮ Previous
Next ❯

Citations

Jul 12, 2013·Molecular and Cellular Biochemistry·Yuqiong WuBing Fang
Sep 19, 2019·Acta Cirúrgica Brasileira·Degong MuXizheng Zhang
Jul 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaoqin YuLiang Li
Aug 8, 2015·Physics in Medicine and Biology·Zhengyi HuDavid W Holdsworth
Apr 20, 2013·Biomedical Engineering Online·Wan Zong mingZhang Xi zheng
Jan 3, 2014·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Zong-ming WanXi-zheng Zhang
Dec 30, 2016·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Lei TanDong Zhu
Oct 18, 2020·Current Osteoporosis Reports·Sarah E Little-LetsingerMaya Styner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Sport Nutrition and Exercise Metabolism
Liang TangLijun Sun
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Julienne E M BrouwersRik Huiskes
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan
WenPing ZhangTorao Ishida
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Tianhua ChenLiang Li
© 2022 Meta ULC. All rights reserved