High-frequency dominant depression of peripheral vagal control of heart rate in rats with chronic heart failure

Acta Physiologica
T KawadaMasaru Sugimachi

Abstract

To examine whether dynamic characteristics of the peripheral vagal control of heart rate (HR) are altered in chronic heart failure (CHF). The right vagal nerve was electrically stimulated according to a binary white noise signal, and the transfer function from vagal nerve stimulation (VNS) to HR was estimated in the frequency range from 0.01 to 1 Hz in five control rats and five CHF rats under anaesthetized conditions. The rate of VNS was changed among 10, 20 and 40 Hz. A multiple linear regression analysis indicated that the increase in the VNS rate augmented the ratio of the high-frequency (HF) gain to the steady-state gain in the control group but not in the CHF group. As a result, the dynamic gain of the transfer function in the frequencies near 1 Hz decreased more in the CHF group than in the control group. Changes in the dynamic characteristics of the peripheral vagal control of HR may contribute to the manifestation of decreased HF components of HR variability observed in CHF.

References

Oct 1, 1991·The American Journal of Physiology·C CeruttiJ Sassard
Jan 1, 1991·The American Journal of Physiology·A A ShoukasE B Haase
Jun 1, 1985·European Heart Journal·A J Riegger
Jan 1, 1989·The American Journal of Physiology·R D BergerR J Cohen
Nov 1, 1971·Circulation Research·M N Levy
Jul 11, 1996·The American Journal of Physiology·T KawadaK Sunagawa
Feb 13, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J C Glantz, S Shomento
Feb 15, 2001·Archives of General Psychiatry·L A Glantz, D A Lewis
Mar 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Tadayoshi MiyamotoKenji Sunagawa
May 29, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Masaki MizunoMasaru Sugimachi
Jul 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaMasaru Sugimachi
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaMasaru Sugimachi
Jun 1, 2010·Experimental Physiology·Masaki MizunoMasaru Sugimachi
Dec 4, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Peter J Schwartz
Jan 29, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Masaki MizunoMasaru Sugimachi

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Citations

Dec 7, 2013·Acta Physiologica·M ZarzosoS V Pandit
Jul 13, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaMasaru Sugimachi
Oct 17, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Toru KawadaMasaru Sugimachi
Apr 24, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaMasaru Sugimachi

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