Abstract
In a primate model of Parkinson's disease (PD), the benefit of extradural motor cortex stimulation (EMCS) was associated with high-frequency stimulation (130 Hz), whereas no significant motor improvement was achieved at 10 Hz or intermediate frequencies of stimulation. We report the case of a 72-year-old female patient affected by severe PD who underwent bilateral EMCS. In baseline med-off condition the patient was unable to arise from a chair and to stand without assistance. Stimulation at 3 and 60 Hz failed to provide any improvement of symptoms, whereas, when stimulating at 130 Hz, axial akinesia and walking improved consistently: the patient, in med-off condition, was able to arise from chair and to walk without assistance. The patient underwent two brain 99mTc- Ethylcysteinate Dimer-SPECT studies: semiquantitative and Statistical Parametric Mapping revealed that the regional cerebral perfusion was significantly increased in the supplementary motor area during stimulation at 130 Hz. After five months, the benefit of EMCS gradually disappeared.
References
Dec 2, 2004·Neuron·Xavier DrouotStéphane Palfi
Jun 29, 2005·Annals of Neurology·Adam M KossJay L Shils
Jul 1, 2005·Acta Neurochirurgica. Supplement·C A PagniF Zenga
May 13, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·M F ContarinoA Albanese
Jul 4, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Gary W ThickbroomFrank L Mastaglia
Oct 5, 2006·Journal of Neural Transmission. Supplementum·P Brown
Feb 17, 2007·Lancet Neurology·Alberto Priori, Jean-Pascal Lefaucheur
Jun 9, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Naoki TaniToshiki Yoshimine
Aug 19, 2007·Acta Neurochirurgica. Supplement·B Cioni, M Meglio
Sep 27, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Antonio P StrafellaElena Moro
Citations
Jun 8, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alfonso FasanoAlfredo Berardelli
Dec 4, 2010·Brain : a Journal of Neurology·Anke H SnijdersIvan Toni
Jun 8, 2011·Brain : a Journal of Neurology·Elena MoroAndres M Lozano
Jun 28, 2012·Nuclear Medicine Communications·Daniela Di GiudaAlessandro Giordano
Jul 2, 2009·Chaos·Anne Beuter, Julien Modolo
Oct 12, 2013·Neuroscience and Biobehavioral Reviews·David Lindenbach, Christopher Bishop
Jan 15, 2015·Nature Reviews. Neurology·Alfonso FasanoBastiaan R Bloem
Jun 14, 2016·Parkinson's Disease·Antonio DanieleDavide Seripa
Dec 3, 2009·Expert Review of Neurotherapeutics·Jean-Pascal Lefaucheur
Dec 23, 2016·Annals of Neurology·Alfonso FasanoMichael D Fox
Feb 6, 2015·The Journal of Physiology·Dany ArsenaultFrancesca Cicchetti
Dec 14, 2019·Brain : a Journal of Neurology·Matteo BolognaAlfredo Berardelli
Aug 2, 2012·Neurologia Medico-chirurgica·Youichi Saitoh
Jul 14, 2012·Neurosurgery·Anna Rita BentivoglioBeatrice Cioni
Mar 12, 2015·Journal of Parkinson's Disease·Alfonso FasanoNicolaas I Bohnen
Aug 2, 2017·Parkinson's Disease·Dustin AndersonFang Ba
Oct 22, 2020·NPJ Parkinson's Disease·Carla PianoAntonio Daniele
Apr 4, 2021·Brain Sciences·Carla PianoTommaso Tufo