High-frequency focal repetitive cerebellar stimulation induces prolonged increases in human pharyngeal motor cortex excitability

The Journal of Physiology
Dipesh H VasantS Hamdy

Abstract

Neurostimulation is a rapidly emerging approach to swallowing rehabilitation, but cerebellar stimulation has not been explored as a treatment. Such proposed therapies for post-stroke dysphagia have required confirmation of physiological effects and optimisation of parameters in healthy humans prior to translational progression into patient groups. There is strong evidence for a role of the cerebellum in swallowing physiology, but this relationship has been under-explored. Recently, single pulses of cerebellar magnetic stimulation have been shown to directly evoke responses from pharyngeal musculature and produce short-term enhancement of cortico-pharyngeal motor evoked potentials, suggesting the feasibility of a cerebellar approach to neurostimulation in the swallowing system. We therefore examined multiple parameters of repetitive cerebellar magnetic stimulation and have described the optimal settings to provoke longer-lasting changes in swallowing neurophysiology. Based on evidence from the post-stroke dysphagia neurostimulation literature, these changes may have a therapeutic potential for swallowing rehabilitation. Brain neurostimulation has been shown to modulate cortical swallowing neurophysiology in post-stroke dysphagia...Continue Reading

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Citations

Dec 30, 2016·The Cerebellum·Kim van DunPeter Mariën
May 27, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A Sasegbon, S Hamdy
Feb 22, 2016·Current Gastroenterology Reports·Emilia MichouShaheen Hamdy
Apr 27, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Dipesh H VasantShaheen Hamdy
Feb 1, 2017·The Kaohsiung Journal of Medical Sciences·Zhuo WangLiang Wang
Aug 28, 2018·Current Physical Medicine and Rehabilitation Reports·Kensuke YamamuraKeiichiro Okamoto
Jan 5, 2021·Journal of Nutritional Science and Vitaminology·Risa SantaKenichi Shibuya
Mar 7, 2021·Dysphagia·Ayodele Sasegbon, Shaheen Hamdy
Oct 17, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ivy Cheng, Shaheen Hamdy

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