PMID: 6977502Feb 15, 1982Paper

High-frequency generation of new immunoresistant tumor variants during metastasis of a cloned murine tumor line (ESb)

International Journal of Cancer. Journal International Du Cancer
K Bosslet, V Schirrmacher

Abstract

A metastatic variant of a chemically induced lymphoma (ESb) from a DBA/2 mouse was found to activate in syngeneic hosts specific anti-tumor cytolytic T lymphocytes (CTL) which recognized on the tumor a distinct tumor-associated antigen. Upon metastasis of a cloned ESb tumor line from an s.c. site to the spleen, the tumor cells which were originally sensitive to lysis by anti-ESb CTL became specifically immunoresistant. The development of immunoresistant variants after tumor-cell transplantation followed a refined kinetic and organ pattern: they were first detected in the spleen, then also in the liver and in the late stage of tumor progression they were the predominant tumor type in all involved organs. No immunoresistant tumor variants were generated in immunoincompetent animals such as nude (nu/nu) mice. Immunoresistant variants also developed when immunosensitive ESb clones were inoculated into animals specifically preimmunized against ESb. In fact, these variants were the only type of cells eventually growing out from such animals causing death from metastasis in spite of the specific immune status of the host. The change of tumor antigen expression described here differs from antibody-induced antigenic modulation in that i...Continue Reading

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Citations

Jan 1, 1982·Cancer Metastasis Reviews·V SchirrmacherL Beck
Jan 1, 1983·Cancer Metastasis Reviews·J E Talmadge
Jan 1, 1984·Cancer Metastasis Reviews·G L Nicolson
Apr 1, 1984·Clinical & Experimental Metastasis·G L Nicolson
Jan 1, 1992·Immunologic Research·I P Witz, M Ran
Jan 1, 1990·Molecular Aspects of Medicine·T N Dear, R F Kefford
Nov 15, 1983·International Journal of Cancer. Journal International Du Cancer·F MartinM Martin
Jun 15, 1983·International Journal of Cancer. Journal International Du Cancer·R Hentschel, E Kölsch
Nov 1, 1988·Japanese Journal of Cancer Research : Gann·Y WatanabeM Kobayashi
Nov 15, 1986·International Journal of Cancer. Journal International Du Cancer·P AltevogtV Schirrmacher
Jan 15, 1983·International Journal of Cancer. Journal International Du Cancer·D A ChowA H Greenberg
Apr 15, 1984·International Journal of Cancer. Journal International Du Cancer·D A Chow
Nov 15, 1982·International Journal of Cancer. Journal International Du Cancer·R DzarlievaN F Fusenig
Mar 15, 1985·International Journal of Cancer. Journal International Du Cancer·G W Brown, D A Chow
Jan 1, 1983·Cancer Metastasis Reviews·P Frost, R S Kerbel
May 8, 2021·Cancer Metastasis Reviews·Sugandha Saxena, Rakesh K Singh
Mar 1, 1987·Current Problems in Surgery·I J Fidler, C M Balch

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