High-frequency linear rheology of hydrogels probed by ultrasound-driven microbubble dynamics

Soft Matter
Akaki JamburidzeValeria Garbin

Abstract

Ultrasound-driven microbubble dynamics are central to biomedical applications, from diagnostic imaging to drug delivery and therapy. In therapeutic applications, the bubbles are typically embedded in tissue, and their dynamics are strongly affected by the viscoelastic properties of the soft solid medium. While the behaviour of bubbles in Newtonian fluids is well characterised, a fundamental understanding of the effect on ultrasound-driven bubble dynamics of a soft viscoelastic medium is still being developed. We characterised the resonant behaviour in ultrasound of isolated microbubbles embedded in agarose gels, commonly used as tissue-mimicking phantoms. Gels with different viscoelastic properties were obtained by tuning agarose concentration, and were characterised by standard rheological tests. Isolated bubbles (100-200 μm) were excited by ultrasound (10-50 kHz) at small pressure amplitudes (<1 kPa), to ensure that the deformation of the material and the bubble dynamics remained in the linear regime. The radial dynamics of the bubbles were recorded by high-speed video microscopy. Resonance curves were measured experimentally and fitted to a model combining the Rayleigh-Plesset equation governing bubble dynamics, with the Kel...Continue Reading

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Citations

Dec 7, 2019·Physical Review Letters·M A BruningA Marin
Oct 14, 2020·Soft Matter·Brice Saint-Michel, Valeria Garbin
Mar 17, 2021·The Journal of Chemical Physics·Chensen LinGeorge Em Karniadakis
Jul 3, 2021·Life·Chunghwan KimWonmo Kang
Nov 13, 2021·Chemical Reviews·Athanasios G AthanassiadisPeer Fischer

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