High frequency mechanical ventilation in severe hyaline membrane disease an alternative treatment?

Critical Care Medicine
R D BlandJ L Woodson

Abstract

Twenty-four preterm infants with respiratory failure from severe hyaline membrane disease (HMD) received mechanical ventilation at high respiratory frequencies. The average birthweight of the infants was 1244 +/- 301 g, and 7 babies weighed less than 1000 g. The average gestational age was 30 +/- 2 weeks, and 6 infants were born at 28 weeks or less. The method of ventilation included (1) respiratory frequencies of 60--110/min, sometimes with brief manual ventilation at more rapid rates, (2) peak inflation pressures (PIP) of less than 35 cm H2O, (3) inspiratory durations of 0.15--0.25 sec, (4) positive end-expiratory pressure (PEEP) of 4--9 cm H2O, and (5) weaning from mechanical ventilation by reducing tidal volume until peak inflation pressure (PIP) reached 20--25 cm H2O, whereupon respiratory frequency was decreased. PaCO2 was kept at 30--40 torr and PaO2 at 60--80 torr. Of the infants, 22 survived (92%) with few major complications.

Citations

Sep 1, 1987·European Journal of Pediatrics·A Greenough, A D Milner
Aug 1, 1995·The Journal of Pediatrics·T E PaulsonB M Peterson
Jan 1, 1996·Annals of Surgery·T T NguyenD N Herndon
Oct 1, 1990·Archives of Disease in Childhood·A Greenough
Jul 1, 1988·The American Review of Respiratory Disease·A S Slutsky
Jan 1, 1991·International Journal of Technology Assessment in Health Care·G Sedin
Oct 26, 2013·Current Problems in Surgery·Dean HollandBrett D Arnoldo
Aug 1, 1988·Pediatric Annals·S J Boros, M C Mammel
Sep 1, 1987·Acta paediatrica Scandinavica·A GreenoughH Gamsu
Sep 1, 1996·Clinics in Chest Medicine·M C Mammel, D R Bing
Jan 1, 1990·Upsala Journal of Medical Sciences·A JonzonG Sedin
Nov 1, 1987·Pediatric Pulmonology·M C Mammel, S J Boros
Sep 1, 1987·Pediatric Pulmonology·A Greenough, F Greenall
Jan 1, 1989·Pediatric Pulmonology·F GonzalezP Richardson
Jan 1, 1991·Journal of Perinatal Medicine·J MorgensternP Wolf
May 1, 1983·Anaesthesia and Intensive Care·H WarkA Berry
Jan 1, 1994·Journal of Perinatal Medicine·A D Edwards
Feb 7, 1994·Journal of Intensive Care Medicine·J H Cronin
Aug 1, 1986·Anaesthesia and Intensive Care·M R Crawford
Jan 1, 1991·International Journal of Technology Assessment in Health Care·W A Hodson
Jan 1, 1997·Journal of Perinatal Medicine·F C Battaglia, A M Marconi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.