High frequency of apolipoprotein E epsilon 2 allele in hemorrhage due to cerebral amyloid angiopathy

Annals of Neurology
J A NicollH V Vinters

Abstract

From the somewhat conflicting published data on apolipoprotein E (apoE) genotype in hemorrhage due to cerebral amyloid angiopathy (CAA), it is unclear whether apoE genotype influences the risk of CAA-related hemorrhage independently of its association with concomitant Alzheimer's disease (AD). We determined the apoE genotypes of 36 patients presenting with cerebral hemorrhage associated with histologically confirmed CAA. The frequency of apoE epsilon 2 was 0.25 and the frequency of apoE epsilon 4 was 0.18. Patients with CAA-related hemorrhage and concomitant AD pathology (CERAD criteria, n = 17) had a high apoE epsilon 4 frequency, close to that in AD cases without hemorrhage. Patients in whom CAA-related hemorrhage occurred in the absence of significant AD pathology (n = 13) had an apoE epsilon 4 frequency somewhat lower than non-AD controls without hemorrhage. However, in CAA-related hemorrhage, the apoE epsilon 2 frequency was high regardless of whether significant AD pathology was present. We conclude that whereas possession of apoE epsilon 2 may be a risk factor for cerebral hemorrhage due to CAA, apoE epsilon 4 is a risk factor for concomitant AD but not an independent risk factor for CAA-related hemorrhage.

References

Oct 1, 1992·Journal of the Neurological Sciences·H V Vinters
May 11, 1991·Lancet·P R WenhamG Blandell
Jan 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J DavignonC F Sing
Mar 1, 1987·Stroke; a Journal of Cerebral Circulation·H V Vinters
Nov 25, 1995·Lancet·R N Kalaria, D R Premkumar
Apr 21, 1995·The Journal of Biological Chemistry·M J LaDuM T Falduto
Sep 18, 1993·Lancet·J PoirierS Gauthier
Nov 1, 1993·Annals of Neurology·R MayeuxH Ginsberg
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D E SchmechelA D Roses
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Feb 1, 1996·Stroke; a Journal of Cerebral Circulation·Y ItohE Otomo
Jan 17, 1996·Annals of the New York Academy of Sciences·R N KalariaD R Premkumar
Apr 1, 1996·Brain Pathology·H V VintersD L Secor

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Citations

Jul 12, 2002·Annals of Neurology·David T WinklerMathias Jucker
Jun 1, 1997·Annals of Neurology·S M Greenberg, B T Hyman
Nov 8, 2006·Acta Neuropathologica·K A Jellinger, J Attems
Nov 8, 2006·Acta Neuropathologica·Dimitri TrembathChristine M Hulette
Jun 10, 2003·Current Atherosclerosis Reports·Eric E Smith, Steven M Greenberg
May 9, 2012·Current Atherosclerosis Reports·Eitan Auriel, Steven Mark Greenberg
Jul 7, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Navdeep Sangha, Nicole R Gonzales
May 9, 2013·Brain Research·Maximilian GahrCarlos Schönfeldt-Lecuona
Oct 24, 2003·Brain Research. Brain Research Reviews·Annemieke A M RensinkMarcel M Verbeek
Apr 25, 2003·Experimental and Molecular Pathology·Ilene D AuerbachHarry V Vinters
Mar 15, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·F L MastagliaB A Kakulas
Jan 29, 2000·The New England Journal of Medicine·H C O'DonnellS M Greenberg
Jun 25, 2003·Journal of Neurotrauma·Andrew D KayJames A R Nicoll
Sep 29, 2011·Alzheimer Disease and Associated Disorders·Blossom C M StephanUNKNOWN Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
Nov 26, 2010·Psychiatry and Clinical Neurosciences·Masatoshi TakedaRamón Cacabelos
Feb 15, 2000·Annals of the New York Academy of Sciences·R N Kalaria
May 20, 2000·Annals of the New York Academy of Sciences·S M GreenbergG W Rebeck
May 20, 2000·Annals of the New York Academy of Sciences·M O McCarron, J A Nicoll
Sep 27, 2005·Journal of Medical Genetics·J-C BecherJ Bell
Jan 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·P D LeclercqS M Gentleman
Apr 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·T HamaguchiM Yamada
Feb 18, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·C SmithJ A R Nicoll
May 20, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·M YamadaH Mizusawa
Aug 4, 2007·BMC Medical Genetics·Ritesh KaushalRanjan Deka
Apr 14, 2007·Molecular Neurodegeneration·Suzanne E WahrleDavid M Holtzman
Apr 3, 2012·Neurosurgical Focus·Prachi MehndirattaWarren R Selman
May 27, 2009·International Journal of Molecular Sciences·Samir Kumar-Singh
May 1, 2008·The British Journal of Radiology·D S Knopman
Feb 18, 2016·Acta Neuropathologica·Leon M TaiGuojun Bu
Dec 30, 2015·Acta Neuropathologica·Seth Love, J Scott Miners
Jul 31, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K A JellingerJ Attems
Apr 15, 2006·Brain Pathology·Martin C HerzigMathias Jucker

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