High frequency of BF mosaic genomes among HIV-1-infected children from Sao Paulo, Brazil

Archives of Virology
Cristina Mendes de OliveiraLuis Fernando de Macedo Brígido

Abstract

HIV-1 genetic diversity information from a pediatric population is scarce. This study enrolled 128 children living with HIV/AIDS, 103 antiretroviral-treated and 25 naive, from the Sao Paulo metropolitan area. Gag, pol and env regions were amplified, and drug resistance mutations, V3 loop, tropism and viral clades were evaluated. Drug resistance mutations among naïve children infected by vertical transmission were uncommon (4.2%), whereas most ARV-experienced children showed extensive mutation patterns. Clade B predominated at the pol region, but the analysis of the three regions concatenated showed 28% with BF mosaic structures. The most common V3 motif was GPGR, followed by GWGR in clade B samples and GPGQ in clade F samples. A predicted X4 phenotype was observed in 27%, without correlation to HIV clade. These findings expand the limited information on molecular characteristics of HIV-1 among children living with HIV/AIDS in the area and may provide information useful for monitoring the epidemic.

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Citations

Mar 26, 2010·AIDS Research and Human Retroviruses·Rosangela RodriguesLuis Fernando de Macedo Brigido
May 15, 2013·PloS One·Sabri Saeed SanabaniEsper Georges Kallas
Jan 21, 2010·Journal of Medical Virology·Ludimila Paula Vaz CardosoMariane Martins de Araújo Stefani
Jul 23, 2015·AIDS Research and Human Retroviruses·Sara Nunes VazCarlos Brites
Jul 8, 2019·Virus Research·Juliana Sacramento M SouzaJoana P Monteiro-Cunha

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