High frequency of c-K-ras activation in 3-methylcholanthrene-induced mouse thymomas

Carcinogenesis
A Eva, R W Trimmer

Abstract

Thymic lymphomas were induced in RJF mice by percutaneous application of 3-methylcholanthrene (MCA). DNAs from 83% of the tumors analyzed contained a transforming c-K-ras gene. The high frequency of c-K-ras oncogene activation in response to MCA seems to favor the concept that the activation of c-K-ras is related to the specificity of the mutagenic effect of MCA.

Citations

Feb 20, 1991·International Journal of Cancer. Journal International Du Cancer·L R GarrettM A Cuchens
Feb 20, 1991·International Journal of Cancer. Journal International Du Cancer·G CarboneG Parmiani
Jan 1, 1989·Molecular Carcinogenesis·B E WeissmanC J Der
Mar 15, 1989·International Journal of Cancer. Journal International Du Cancer·E M BoltzM L Friedlander
Jan 1, 1990·Chemico-biological Interactions·M R Osborne

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