High frequency of cholestasis in generalized pustular psoriasis: Evidence for neutrophilic involvement of the biliary tract

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Manuelle ViguierH Bachelez

Abstract

Generalized pustular psoriasis is a rare form of psoriasis that is sometimes associated with extracutaneous manifestations. Evidence for biliary involvement has been suggested in isolated cases. We investigated the prevalence and nature of liver abnormalities occurring in this disease. Twenty-two patients consecutively admitted for generalized pustular psoriasis who underwent liver biological tests at the time of the attack and during the following weeks were included. Twenty patients (90%) had at least one abnormal biological liver parameter. Eleven patients (50%) had pronounced abnormalities: jaundice (4/22), gammaglutamyl transferase higher than 5 times the normal value (10/22), alkaline phosphatase higher than twice the normal value (7/22), and/or aminotransferases higher than 3 times the normal value (7/22). These abnormalities returned to normal range at the time of remission of pustular psoriasis, suggesting that severe liver abnormalities could be associated with severe cutaneous disease. Neutrophilic cholangitis was observed on liver biopsy. Persistent magnetic resonance cholangiopancreatography features similar to those observed in sclerosing cholangitis were found in 3 of the 4 patients studied. No causal factor othe...Continue Reading

References

Jan 1, 1978·Dermatologica·T Fredriksson, U Pettersson
Nov 1, 1991·The British Journal of Dermatology·J M McGregorD M MacDonald
Sep 1, 1991·Archives of Dermatology·B D Zelickson, S A Muller
Feb 1, 1991·Journal of the American Academy of Dermatology·B D Zelickson, S A Muller
Nov 1, 1988·Gastroenterology·K BalasubramaniamN F LaRusso
Sep 1, 1987·International Journal of Dermatology·J H Lyons
Dec 1, 1968·The British Journal of Dermatology·H Baker, T J Ryan
Feb 1, 1972·Archives of Dermatology·I M BravermanE O'Keefe
Apr 1, 1973·Archives of Dermatology·W B Reed
May 25, 1974·British Medical Journal·D J WarrenG W Beveridge
Jul 6, 1974·British Medical Journal·J A Craig
Nov 1, 1971·The British Journal of Dermatology·T J Ryan, H Baker
Jan 1, 1969·Dermatologica·M GordonC F Burgoon
Dec 1, 1984·Journal of the American Academy of Dermatology·W R Hubler
Apr 6, 1995·The New England Journal of Medicine·Y M Lee, M M Kaplan
Jan 1, 1995·Dermatology : International Journal for Clinical and Investigative Dermatology·S Kawana, S Nishiyama
Jan 1, 1994·The Journal of Pediatrics·D DebrayO Bernard
Sep 1, 1993·Pediatric Dermatology·R A IvkerJ M Grant-Kels
Apr 1, 1997·International Journal of Dermatology·Y K Tay, S N Tham
Jul 21, 2000·Radiographics : a Review Publication of the Radiological Society of North America, Inc·K M VitellasR C Nelson
Dec 21, 2000·The British Journal of Dermatology·S P LiS N Wong
May 25, 2002·Pediatric Radiology·Calogero FerraraAndrea Giovagnoni
Jun 22, 2002·Dermatology : International Journal for Clinical and Investigative Dermatology·Yasuhiro MiyazakiKiyoshi Nishioka

❮ Previous
Next ❯

Citations

Apr 19, 2011·American Journal of Clinical Dermatology·João Borges-CostaManuel Marques Gomes
Feb 19, 2010·Folia Histochemica Et Cytobiologica·Aldona PietrzakRobert A Schwartz
Feb 5, 2014·Burns : Journal of the International Society for Burn Injuries·Katherine M VarmanLouis R Pizano
Oct 14, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Bohdan PomahacAllen Liu
May 11, 2012·Annales de dermatologie et de vénéréologie·H Bachelez
Sep 21, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Umberto ArenaMassimo Pinzani
Jul 16, 2010·La Revue de médecine interne·S BenomarB Hassam
Sep 20, 2015·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Tomomi FujisawaMariko Seishima
Sep 23, 2008·Gastroentérologie Clinique Et Biologique·P-Y GiraultY Veran
May 24, 2008·Annales de dermatologie et de vénéréologie·E Delaporte
Nov 21, 2007·Clinics in Dermatology·Luigi Naldi, Daniele Gambini
Sep 14, 2012·The British Journal of Dermatology·P DieudeH Bachelez
Mar 31, 2005·Joint, Bone, Spine : Revue Du Rhumatisme·Louis Dubertret
Jan 18, 2014·Autoimmunity Reviews·Smriti K RaychaudhuriSiba P Raychaudhuri
Oct 21, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·A FinetUNKNOWN Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie
Apr 24, 2016·The British Journal of Dermatology·P SkendrosK Ritis
Feb 27, 2016·The Australasian Journal of Dermatology·Elona TulaErol Avsar
Nov 23, 2016·Pediatric Dermatology·Diane PourchotUNKNOWN Groupe de Recherche de la Société Française de Dermatologie Pédiatrique
Jan 16, 2018·The British Journal of Dermatology·H Bachelez
Mar 25, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·K M HoeglerR A Schwartz
Jun 1, 2018·Experimental Dermatology·Alexander BoehnerKilian Eyerich
Sep 6, 2019·Expert Review of Clinical Immunology·Melinda J GooderhamMark G Lebwohl
Mar 17, 2018·BioMed Research International·Marco FioreGiovanni Damiani
Jan 27, 2021·Dermatologic Therapy·Christian KromerDagmar Wilsmann-Theis
Aug 18, 2021·Expert Review of Clinical Immunology·Mayumi Komine, Akimichi Morita
Aug 28, 2021·International Journal of Molecular Sciences·Dominik SamotijAdam Reich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved