PMID: 8595153Feb 1, 1996Paper

High frequency of chromosome 9 deletion in ovarian cancer: evidence for three tumour-suppressor loci

British Journal of Cancer
J DevlinM A Knowles

Abstract

We have screened 33 ovarian tumours of various grades and stages for the loss of heterozygosity (LOH) of markers on chromosome 9. LOH was detected in 26 cases (79%). Eleven tumours (33%) showed LOH of all informative markers. The remaining 15 cases had partial deletions. Of these, six (18%) had losses on 9p only, three (9%) had LOH confined to 9q and six (18%) had losses on both chromosome arms, four of which had a retention of hetereozygosity in between. There was no association between tumour grade stage or histopathology and any losses. High-density deletion mapping was carried out in 12 selected cases that had partial deletions of 9p and/or 9q. The deleted region on 9p included the cyclin-dependent kinase inhibitor 2 (CDKN2) locus and one tumour was found to have a homozygous deletion of CDKN2. LOH on 9q extended over a larger region. We found evidence for two regions of deletion on 9q, one at 9q34 and the other encompassing the nevoid basal cell carcinoma (Gorlin) syndrome locus on proximal 9q.

Citations

Mar 4, 1997·International Journal of Cancer. Journal International Du Cancer·Y C ShihG Chenevix-Trench
Mar 30, 2001·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·W ZedanA S High
Oct 20, 2012·BMC Medical Genomics·Ruby Yunju HuangLiang Goh
Sep 2, 1999·British Journal of Cancer·D NiederacherM W Beckmann
Feb 18, 2005·Journal of Korean Medical Science·Hee Yeon WooSun Hee Kim
Apr 10, 2008·Human Molecular Genetics·Louis S PymarMargaret A Knowles
Jan 31, 2015·American Journal of Respiratory and Critical Care Medicine·Li ZhangJoel Moss
May 9, 2012·Expert Opinion on Therapeutic Targets·Carman K M Ip, Alice S T Wong
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Nov 21, 1998·Biochimica Et Biophysica Acta·M Ruas, G Peters

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