High Frequency of Class 1 Integrons in Escherichia coli Isolated From Patients With Urinary Tract Infections in Yasuj, Iran

Iranian Red Crescent Medical Journal
Seyed Sajjad KhoramroozSeyed Abdolmajid Khosravani

Abstract

Most urinary tract infections (UTI) are caused by Escherichia coli. Integrons have an important role in distributing antibiotic resistance genes among bacteria. The aim of this study was to investigate the presence of class 1, 2 and 3 integrons and their association with antibiotic resistance in E. coli isolated from patient with UTI in Yasuj, Iran. In this cross-sectional study a total of 200 E. coli were collected from 1820 patients diagnosed with UTI that had been referred to two clinical laboratories between February 2013 and November 2014 in Yasuj city, southwest of Iran. Susceptibility of isolates to 11 different antibiotics was determined by the disk agar diffusion method. multiplex-polymerase chain reaction (PCR) was used for detection of class 1, 2 and 3 integrons. The data were analyzed using the SPSS software (version 16) and the chi-square test. A P value of < 0.05 was considered statistically significant. The highest rate of resistance was observed toward cephalothin (99%) and amoxicillin (76%) while only two (1%) isolates showed resistance to imipenem. Overall, 79% of isolates were multi drug resistant (MDR). Class 1 and 2 integrons were detected in 104 (52%) and 5 (2.5%) isolates respectively, while none of the i...Continue Reading

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Citations

Jul 5, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Azer Özad DüzgünSedanur Cinemre
Oct 10, 2019·Infectious Disorders Drug Targets·Narges Habibollah-PourzereshkiFatemeh Keshavarz-Saleh

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

SPSS

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