High frequency of contact allergy to implant and bone cement components, in particular gentamicin, in cemented arthroplasty with complications: usefulness of late patch test reading

Contact Dermatitis
Benjamin ThomasPeter Thomas

Abstract

Arthroplasty patients with complications may be sensitized to implant components. To quantify patch test reactions to implant materials in aseptic cemented arthroplasty patients with complications, and to evaluate the benefit of late patch test reading at D6. Analyses of patch test reactions to baseline series and bone cement components and of the questionnaire-aided histories of 250 consecutive patients with suspected implant allergy were performed. Patch tests were read at D2, D3, and D6. There were 187 positive reactions to the 29 allergens of the baseline series, and 52 to the seven allergens of the bone cement series. Forty-nine of 250 patients reacted to the bone cement series. In contrast to 'early allergens' such as fragrance mix, late reading at D6 increased the number of positive reactions by 11/32 for nickel, 1/5 for cobalt, and 2/4 for chromium. With bone cement components, most reactions were to gentamicin (25 of 250 patients), and 17 of 25 appeared only at D6. Late reading is useful for patch tests with metals and bone cement components. With only D2/D3 readings, 32 reactions to nickel, cobalt, chromium and bone cement components would have been missed. This underlines the utility of late reading in general and in...Continue Reading

References

Jun 1, 1978·Contact Dermatitis·J C Mitchell
Nov 1, 1989·Contact Dermatitis·L MassoneV Isola
Feb 1, 1989·Contact Dermatitis·A W MacfarlaneC M King
Feb 1, 1980·Acta Orthopaedica Scandinavica·H Wahlig, E Dingeldein
Aug 1, 1996·Clinical Orthopaedics and Related Research·K Merritt, S A Brown
Mar 12, 1999·Contact Dermatitis·J GeierT Fuchs
Nov 20, 2002·Clinical Orthopaedics and Related Research·Peter F SharkeySidney M Jacoby
Jan 31, 2003·Der Orthopäde·S J Breusch, K-D Kühn
Apr 18, 2003·The Journal of the American Academy of Orthopaedic Surgeons·Thomas N JosephPaul E Di Cesare
Oct 14, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·N Hallab
Dec 25, 2007·Biomaterials·Donatella GranchiArmando Giunti
Jan 30, 2008·Der Orthopäde·P ThomasM Thomsen
May 13, 2008·Dental Materials : Official Publication of the Academy of Dental Materials·Arne F BoecklerKarl-Ernst Dette
Feb 5, 2009·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Karin-Almut DietrichPeter Thomas
Mar 6, 2009·Contact Dermatitis·Michael Haeberle, Bernd Wittner
Oct 20, 2009·Indian Journal of Orthopaedics·Amit K SrivastavShekhar Agarwal
Feb 2, 2011·The Journal of Bone and Joint Surgery. British Volume·D J LangtonK A De Smet
Sep 10, 2011·Orthopedics·Steven J Fitzgerald, Robert T Trousdale
Oct 5, 2011·The Journal of Bone and Joint Surgery. British Volume·A J HartJ A Skinner
Jun 2, 2012·Dermatitis : Contact, Atopic, Occupational, Drug·Mark D P DavisSara A Farmer
Jan 8, 2013·Contact Dermatitis·Jakob Torp Madsen, Klaus Ejner Andersen
Feb 20, 2015·Expert Review of Clinical Immunology·Peter Thomas, Burkhard Summer

❮ Previous
Next ❯

Citations

Nov 7, 2015·Der Orthopäde·I J BankeH Gollwitzer
Apr 23, 2016·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·P Thomas
Apr 27, 2016·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M ThomsenP Thomas
Mar 13, 2018·Contact Dermatitis·Diana WittmannPeter Thomas
Mar 11, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·B SummerP Thomas
Jul 11, 2019·Contact Dermatitis·Monica CorazzaAlessandro Borghi
Sep 21, 2016·Dermatitis : Contact, Atopic, Occupational, Drug·Peter C SchalockJoel DeKoven
Jul 19, 2017·Dermatitis : Contact, Atopic, Occupational, Drug·Hafsa M ChaudhryMark D P Davis
Aug 21, 2021·Dermatitis : Contact, Atopic, Occupational, Drug·Anton de Groot

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
P Thomas, M Thomsen
Acta Dermato-venereologica
S Fregert, H Rorsman
Annales de dermatologie et de vénéréologie
R Tomb
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology
S Harada, T Masuda
© 2021 Meta ULC. All rights reserved