High frequency of deletional alpha-thalassemia in beta-thalassemia trait: implications for genetic counseling

American Journal of Hematology
I PanigrahiR Saxena

Abstract

Thalassemias are a group of genetic hemolytic disorders with varying phenotypes. In this study, the frequency of alpha globin gene deletions was studied in the beta-thalassemia trait, the mildest form of the disorder. Eleven out of 33 (33%) individuals were positive for alpha(-3.7 kb) deletions. None of the subjects was positive for the Southeast Asian deletion. Such a high frequency for alpha deletions has not been reported earlier in thalassemia minor. Hematological parameters are compared, and implications of this finding for genetic counseling are discussed.

Citations

Nov 30, 2006·Journal of Applied Genetics·Vaikam H SankarSarita Agarwal
Dec 17, 2009·European Journal of Applied Physiology·Imed TouhamiDaniel Le Gallais

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