High frequency of highly active antiretroviral therapy modifications in patients with acute or early human immunodeficiency virus infection

Pharmacotherapy
Beulah P SabundayoJoseph B Margolick

Abstract

To examine the frequency of highly active antiretroviral therapy (HAART) modifications, the reasons for these modifications, and toxicities of these drugs in patients receiving their first HAART regimen after a diagnosis of acute (< 2 mo from infection) or early (2-12 mo) human immunodeficiency virus (HIV) infection. Fifty-one patients who were enrolled in the Acute Infection and Early Disease Research Program at a Baltimore, Maryland, site between January 1, 1998, and April 30, 2002, and who chose to start HAART. Time from initiation of therapy to first modification-defined as change in any HAART drug without an interruption in therapy or as simultaneous discontinuation of all drugs within the regimen-and time from initiation of therapy to reinitiation of therapy were recorded, as well as reasons for modification and reinitiation. With a median follow-up of 1,549 days, 21 (41%) of 51 patients received HAART continuously, but only 10 (20%) continued to receive their original regimen without any modification. Among the 41 patients (80%) who received modified therapy, the main reasons for the first modification were toxicity (16 patients), nonadherence (8), and new data on treatment efficacy or safety (8). Of 30 patients who stop...Continue Reading

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Citations

Jul 3, 2007·AIDS Research and Human Retroviruses·Wan Beom ParkKang Won Choe
Jun 29, 2012·AIDS·Mikaela SmitFrank de Wolf
Feb 6, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Linda G ApuzzoJoseph B Margolick
Oct 15, 2014·AIDS Research and Human Retroviruses·Rowena E Johnston, Mary M Heitzeg
Jun 18, 2014·Journal of the International Association of Providers of AIDS Care·Marco LoríoCarlos Quant
Jun 2, 2009·Antiviral Chemistry & Chemotherapy·Hans-Jürgen Stellbrink

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