High frequency of lamivudine resistance mutations in Brazilian patients co-infected with HIV and hepatitis B

Journal of Medical Virology
M C Mendes-CorrêaD E Uip

Abstract

This study analyzed the genotype distribution and frequency of lamivudine (LAM) and tenofovir (TDF) resistance mutations in a group of patients co-infected with HIV and hepatitis B virus (HBV). A cross-sectional study of 847 patients with HIV was conducted. Patients provided blood samples for HBsAg detection. The load of HBV was determined using an "in-house" real-time polymerase chain reaction. HBV genotypes/subgenotypes, antiviral resistance, basal core promoter (BCP), and precore mutations were detected by DNA sequencing. Twenty-eight patients with co-infection were identified. The distribution of HBV genotypes among these patients was A (n = 9; 50%), D (n = 4; 22.2%), G (n = 3; 16.7%), and F (n = 2; 11.1%). Eighteen patients were treated with LAM and six patients were treated with LAM plus TDF. The length of exposure to LAM and TDF varied from 4 to 216 months. LAM resistance substitutions (rtL180M + rtM204V) were detected in 10 (50%) of the 20 patients with viremia. This pattern and an accompanying rtV173L mutation was found in four patients. Three patients with the triple polymerase substitution pattern (rtV173L + rtL180M + rtM204V) had associated changes in the envelope gene (sE164D + sI195M). Mutations in the BCP region ...Continue Reading

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Citations

Nov 16, 2010·Virology Journal·Alcione O SantosJuan M Salcedo
Sep 12, 2013·World Journal of Gastroenterology : WJG·Sonia Roman, Arturo Panduro
Apr 28, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Dennis Armando BertoliniJoão Renato Rebello Pinho
Apr 19, 2012·Memórias do Instituto Oswaldo Cruz·Francisco Campello do Amaral MelloSelma de Andrade Gomes

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