High Frequency of Polymicrobial Infections After Surgical Resection of Malignant Bone and Soft Tissue Tumors: A Retrospective Cohort Study

Infectious Diseases and Therapy
Laura M VosDominique Salmon

Abstract

Surgical resection of a malignant bone tumor (BT) or soft tissue tumor (STT), with or without prosthetic replacement, carries a high risk of developing postoperative infections. There is limited knowledge on the bacteriological spectrum of these postsurgical infections that necessitate empirical antibiotic therapy. The aim of this study was to analyze the incidence and microbiological features of site infections following BT or STT resection. In this retrospective mono-center study, we analyzed the surgical and bacteriological data of all consecutive patients who developed an infection after surgical resection of a BT or STT between January 2010 and April 2014. Seventy-two consecutive patients who developed an infection on the site of surgical treatment for a BT (n = 42) or SST (n = 30) were included. Polymicrobism was frequently observed, more often associated with STTs (93%) than BTs (71%; P = 0.03). Gram-negative bacteria were more frequently isolated in STTs (55%) than in BTs (26%; P = 0.01) and non-prosthesis-associated infections (54%) than prosthesis-associated infections (29%; P = 0.04), whereas staphylococci were more frequently found in BTs (76%) than in STTs (52%; P = 0.03). Overall, we found gram negatives in 82% of...Continue Reading

References

Nov 25, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E F BerbariD R Osmon
Apr 5, 2005·The Journal of Bone and Joint Surgery. American Volume·L M JeysR M Tillman
Nov 4, 2008·Annals of Surgical Oncology·Jun Ah LeeDae-Geun Jeon
May 13, 2011·Clinical Orthopaedics and Related Research·Xin LiRichard D Lackman
Nov 15, 2011·The Journal of Arthroplasty·UNKNOWN Workgroup Convened by the Musculoskeletal Infection Society
Mar 1, 2012·Spine·Pietro RuggieriMario Mercuri
Feb 14, 2013·Clinical Orthopaedics and Related Research·Antonella RacanoMichelle Ghert
Jul 3, 2013·Annals of Plastic Surgery·Kyle J SanniecAlanna M Rebecca
Aug 27, 2013·Clinical Orthopaedics and Related Research·Andrea AngeliniPietro Ruggieri
Nov 29, 2013·Journal of Surgical Oncology·Nicole K BehnkeGinger E Holt

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
amputation

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cellulitis

Cellulitis (erysipelas) is a recurring and debilitating bacterial infection of the skin and underlying tissue. Discover the latest research on cellulitis here.