High frequency of silver resistance genes in invasive isolates of Enterobacter and Klebsiella species

The Journal of Hospital Infection
S SütterlinÅ Melhus

Abstract

Silver-based products have been marketed as an alternative to antibiotics, and their consumption has increased. Bacteria may, however, develop resistance to silver. To study the presence of genes encoding silver resistance (silE, silP, silS) over time in three clinically important Enterobacteriaceae genera. Using polymerase chain reaction (PCR), 752 bloodstream isolates from the years 1990-2010 were investigated. Age, gender, and ward of patients were registered, and the susceptibility to antibiotics and silver nitrate was tested. Clonality and single nucleotide polymorphism were assessed with repetitive element sequence-based PCR, multi-locus sequence typing, and whole-genome sequencing. Genes encoding silver resistance were detected most frequently in Enterobacter spp. (48%), followed by Klebsiella spp. (41%) and Escherichia coli 4%. Phenotypical resistance to silver nitrate was found in Enterobacter (13%) and Klebsiella (3%) isolates. The lowest carriage rate of sil genes was observed in blood isolates from the neonatology ward (24%), and the highest in blood isolates from the oncology/haematology wards (66%). Presence of sil genes was observed in international high-risk clones. Sequences of the sil and pco clusters indicate...Continue Reading

Citations

Mar 14, 2018·Antimicrobial Agents and Chemotherapy·Susanne SütterlinMartin C J Maiden
Feb 23, 2019·Critical Reviews in Microbiology·Steven L PercivalRui Chen
Apr 12, 2019·Astrobiology·Gilke De MiddeleerSarah De Saeger
Jul 26, 2018·Acta Microbiologica Et Immunologica Hungarica·Adrienn HanczvikkelÁkos Tóth
Mar 2, 2021·Chemical Engineering Journal·Vignesh KumaravelSuresh C Pillai
Oct 26, 2020·Environmental Research·Guilherme Sgobbi ZaguiLeonardo Neves Andrade
Jul 6, 2021·JAC-antimicrobial Resistance·Jean-Yves MaillardRose Cooper
Feb 8, 2018·The Journal of Hospital Infection·C AdlhartF Crijns

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