High-Frequency Oscillation Networks and Surgical Outcome in Adult Focal Epilepsy

Annals of Neurology
Karina A González OtárulaJean Gotman

Abstract

To investigate whether high-frequency oscillations (HFOs) show spatiotemporal propagation and assess the relevance of the earliest oscillations in relation to the seizure onset zone (SOZ) and postsurgical outcome. We retrospectively investigated the intracerebral electroencephalography (EEG) of patients who became seizure free after subsequent surgery. We marked HFOs during 1 hour of recordings. We calculated the time delay between pairs of channels as the median delay between their HFOs and constructed a time line of the delay of each channel with respect to the earliest channel (first source channel). A network was defined when a temporal order could be established among the channels based on the existence of statistically significant delays. Fifteen patients with good surgical outcome were included. We found ripple networks in all patients, and fast ripple networks in 9. For ripples, first source channels were found in a higher proportion in the SOZ than the rest of the network channels (15 of 27 [56%] versus 93 of 262 [35%]; p = 0.04). For both ripples and fast ripples, first source channels were resected more often that the rest of the network channels (ripples: 13 of 27 [48%] versus 65 of 262 [25%]; p = 0.01; fast ripples...Continue Reading

References

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Jun 7, 2017·Annals of Neurology·Hui Ming KhooJean Gotman
Jul 1, 2017·Epilepsia·Birgit FrauscherJean Gotman
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Citations

Oct 15, 2019·Human Brain Mapping·Jian LiPatrick Chauvel
Feb 26, 2020·Annals of Clinical and Translational Neurology·Eleonora TamiliaChristos Papadelis
Feb 13, 2020·Current Opinion in Neurology·Birgit Frauscher
Jun 2, 2020·Neurosurgery Clinics of North America·Karina A González Otárula, Stephan Schuele
Mar 13, 2021·Annals of Neurology·Eleonora TamiliaChristos Papadelis
Apr 14, 2021·Journal of Neural Engineering·Mariam Al HarrachFabrice Wendling
May 5, 2021·CNS Neuroscience & Therapeutics·Li-Juan ShiJi-Cong Zhang
May 12, 2021·Seizure : the Journal of the British Epilepsy Association·Jing XiangJeffrey Tenney

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