High-frequency oscillations in awake patients undergoing brain tumor-related epilepsy surgery

Neurology
Anteneh M FeyissaAlfredo Quinones-Hinojosa

Abstract

To examine the relationship between high-frequency oscillations (HFOs) and the presence of preoperative seizures, World Health Organization tumor grade, and isocitrate dehydrogenase 1 (IDH1) mutational status in gliomas. We retrospectively studied intraoperative electrocorticography recorded in 16 patients with brain tumor (12 presenting with seizures) who underwent awake craniotomy and surgical resection between September 2016 and June 2017. The number and distribution of HFOs were determined and quantified visually and with an automated HFO detector. Five patients had low-grade (1 with grade I and 4 with grade II) and 11 had high-grade (6 with grade III and 5 with grade IV) brain tumors. An IDH1 mutation was found in 6 patients. Patients with a history of preoperative seizures were more likely to have HFOs than those without preoperative seizures (9 of 12 vs 0 of 4, p = 0.02). The rate of HFOs was higher in patients with IDH1 mutant (mean 7.2 per minute) than IDH wild-type (mean 2.3 per minute) genotype (p = 0.03). HFOs are common in brain tumor-related epilepsy, and HFO rate may be a useful measure of epileptogenicity in gliomas. Our findings further support the notion that IDH1 mutant genotype is more epileptogenic than IDH...Continue Reading

References

Apr 17, 2007·Lancet Neurology·Melanie S M van BreemenCharles J Vecht
Sep 13, 2011·Nature Medicine·Susan C BuckinghamHarald Sontheimer
Mar 1, 2012·Annals of Neurology·Maeike ZijlmansJean Gotman
Jul 31, 2012·Neurology·Tanya I YuenTerence J O'Brien
Jan 12, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ruta GuptaMichael E Buckland
Dec 18, 2013·Epilepsia·André PalminiVinicius Duval Silva
Jul 11, 2014·Science Translational Medicine·Johan PalludGilles Huberfeld
Jun 11, 2015·The New England Journal of Medicine·UNKNOWN Cancer Genome Atlas Research NetworkJianan Zhang
Jun 14, 2015·Neurology·Maryse A van 't KloosterMaeike Zijlmans
Nov 4, 2015·Neuro-oncology·Terri S ArmstrongAndrew D Norden
Nov 6, 2015·Frontiers in Human Neuroscience·Yvonne HöllerEugen Trinka
Mar 12, 2016·Nature Reviews. Neurology·Gilles Huberfeld, Charles J Vecht
Apr 14, 2017·Neurology·Hao ChenCraig Horbinski
Jun 18, 2017·Epilepsia·Maeike ZijlmansMichel Le Van Quyen

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Citations

Aug 21, 2018·Neurologia i neurochirurgia polska·Eric D Goldstein, Anteneh M Feyissa
Jan 23, 2020·Cancer·L Nicolas Gonzalez Castro, Tracey A Milligan
Jun 5, 2021·Journal of Neurosurgery·Tito Vivas-BuitragoAlfredo Quinones-Hinojosa

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