High-Frequency Oscillatory Ventilation in Pediatric Acute Lung Injury: A Multicenter International Experience

Critical Care Medicine
Jordan S RettigJohn H Arnold

Abstract

We aim to describe current clinical practice, the past decade of experience and factors related to improved outcomes for pediatric patients receiving high-frequency oscillatory ventilation. We have also modeled predictive factors that could help stratify mortality risk and guide future high-frequency oscillatory ventilation practice. Multicenter retrospective, observational questionnaire study. Seven PICUs. Demographic, disease factor, and ventilatory and outcome data were collected, and 328 patients from 2009 to 2010 were included in this analysis. None. Patients were classified into six cohorts based on underlying diagnosis. We used univariate analysis to identify factors associated with mortality risk and multivariate logistic regression to identify independent predictors of mortality risk. An oxygenation index greater than 35 and immunocompromise exhibited the greatest predictive power (p < 0.0001) for increased mortality risk, and respiratory syncytial virus was associated with lowest mortality risk (p = 0.003). Differences in mortality risk as a function of oxygenation index were highly dependent on primary underlying condition. A trend toward an increase in oscillator amplitude and frequency was observed when compared wi...Continue Reading

References

Sep 17, 2002·American Journal of Respiratory and Critical Care Medicine·Stephen DerdakUNKNOWN Multicenter Oscillatory Ventilation For Acute Respiratory Distress Syndrome Trial (MOAT) Study Investigators
Jul 1, 2005·Critical Care : the Official Journal of the Critical Care Forum·Fieke Y A M Slee-WijffelsFrans B Plötz
Aug 31, 2006·Pediatric Research·Jonathan MeyerDorothee Bienzle
Feb 6, 2008·Circulation·Howard J Cabral
Jun 18, 2009·Critical Care Medicine·Adrienne G Randolph
Sep 21, 2011·Experimental Biology and Medicine·Carlos Fernando RonchiJose Roberto Fioretto
Jan 24, 2013·The New England Journal of Medicine·Duncan YoungUNKNOWN OSCAR Study Group
Jan 24, 2013·The New England Journal of Medicine·Niall D FergusonUNKNOWN Canadian Critical Care Trials Group
Sep 3, 2014·JAMA Pediatrics·Sandrine EssouriPhilippe Jouvet
Sep 3, 2014·JAMA Pediatrics·Martin C J KneyberDick G Markhorst
Sep 3, 2014·JAMA Pediatrics·Peter C Rimensberger, Thomas E Bachman

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Citations

Jun 1, 2016·Frontiers in Pediatrics·Nadir Yehya, Neal J Thomas
Aug 9, 2016·Expert Review of Respiratory Medicine·Joel Kian Boon LimIra M Cheifetz
Feb 18, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ronald WongChristopher J Newth
Apr 4, 2018·Pediatric Pulmonology·Claire A StewartRanjit S Chima
Jan 12, 2020·Indian Journal of Pediatrics·Arpita ChattopadhyayRakesh Lodha
Aug 5, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Aaron C SpicerAnil Sapru
Apr 18, 2017·F1000Research·Nicolas NardiPhilippe Jouvet
Nov 18, 2015·Critical Care Medicine·James D Fortenberry
Mar 24, 2018·International Journal of Molecular Medicine·Zewu Dong, Yufang Yuan
Dec 23, 2020·Pediatric Pulmonology·Jean-Eudes PiloquetNoëlla Lodé

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