High-frequency partial liquid ventilation in respiratory distress syndrome: hemodynamics and gas exchange

Journal of Applied Physiology
M SukumarC L Leach

Abstract

Partial liquid ventilation using conventional ventilatory schemes improves lung function in animal models of respiratory failure. We examined the feasibility of high-frequency partial liquid ventilation in the preterm lamb with respiratory distress syndrome and evaluated its effect on pulmonary and systemic hemodynamics. Seventeen lambs were studied in three groups: high-frequency gas ventilation (Gas group), high-frequency partial liquid ventilation (Liquid group), and high-frequency partial liquid ventilation with hypoxia-hypercarbia (Liquid-Hypoxia group). High-frequency partial liquid ventilation increased oxygenation compared with high-frequency gas ventilation over 5 h (arterial oxygen tension 253 +/- 21.3 vs. 17 +/- 1.8 Torr; P < 0.001). Pulmonary vascular resistance decreased 78% (P < 0.001), pulmonary blood flow increased fivefold (P < 0.001), and aortic pressure was maintained (P < 0.01) in the Liquid group, in contrast to progressive hypoxemia, hypercarbia, and shock in the Gas group. Central venous pressure did not change. The Liquid-Hypoxia group was similar to the Gas group. We conclude that high-frequency partial liquid ventilation improves gas exchange and stabilizes pulmonary and systemic hemodynamics compared ...Continue Reading

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Citations

Jun 19, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·B P Fuhrman
Jun 19, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ellen M. Bendel-StenzelMark C. Mammel
May 5, 2005·Journal of Biomechanical Engineering·Vinod SureshRonald B Hirschl
Jan 4, 2006·Annals of Biomedical Engineering·Chris D Bertram, Donald P Gaver
Jul 8, 2009·Pediatric Research·Tommi NoponenVineta Fellman
Mar 9, 2005·Critical Care Medicine·Robert M Kacmarek, Atul Malhotra
Dec 18, 2001·Pediatric Pulmonology·Mei-Jy JengBetau Hwang
Apr 15, 1999·Current Opinion in Pediatrics·C M Weis, W W Fox
Aug 4, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Alexandre T RottaBradley P Fuhrman
Apr 25, 2007·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Frédéric GerberPhilippe Fontaine
May 25, 2001·Current Opinion in Critical Care·J D Ricard, F Lemaire

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