High-frequency stimulation of the atria increases early recurrence following pulmonary vein isolation in patients with persistent atrial fibrillation

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Akinori SairakuYasuki Kihara

Abstract

High-frequency stimulation (HFS) of the atria induces atrial fibrillation (AF) when applied during sinus rhythm and elicits a parasympathetic response when delivered at sites where ganglionated plexi (GPs) are located. However, little is known about its impact after an electrophysiological study. To evaluate the impact of HFS on the short-term and long-term outcomes after the ablation of persistent AF. Thirty consecutive patients with persistent or long-standing persistent AF were randomly assigned to either receive HFS of the left atrium (n = 15) or not (n = 15) during their electrophysiological studies. Patients receiving HFS were examined to determine whether or not a vagal response was elicited by the HFS at sites where GPs were located before and after conventional pulmonary vein isolation without any ablation targeting the GPs. Patients not receiving the HFS underwent the ablation procedure alone. The rate of recurrence of AF within 3 months of the procedure (early recurrence [ER]) and the frequency of that occurring after that period (late recurrence) were compared between the patient groups. The incidence of ER occurred more frequently in patients with HFS than in those without (80% vs 40%; P = .015), whereas the occurr...Continue Reading

References

Jan 11, 2003·Journal of Cardiovascular Electrophysiology·Masamichi HiroseMark D Carlson
Sep 23, 2006·Journal of Cardiovascular Electrophysiology·Aamir CheemaHugh Calkins
Jul 1, 2009·Journal of Cardiovascular Electrophysiology·Sunny S PoWarren M Jackman
Dec 1, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hiroshi NakagawaWarren M Jackman
Jan 5, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Demosthenes G KatritsisA John Camm
Jul 26, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Akinori SairakuYasuki Kihara
Jan 5, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Lilei YuSunny S Po

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Citations

Jun 5, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Robert Lemery
Jun 15, 2019·Nature Reviews. Cardiology·Neil HerringDavid J Paterson

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