High-frequency ultrasound imaging for cutaneous neurofibroma in patients with neurofibromatosis type I

European Journal of Dermatology : EJD
Delphine RaffinLaurent Machet

Abstract

Neurofibromas (NFs) are benign tumours arising from a nerve sheath, which are present in nearly all patients with neurofibromatosis type 1 (NF1). High-frequency ultrasound (HFU) systems, using frequencies over 20 MHz, were developed to improve visualization of skin tumours by means of increased resolution. To describe NFs by using HFU in patients with NF1. Anonymized HFU (25-MHz) images of NFs were randomized. Initially, two dermatologist investigators, with experience in HFU imaging of the skin, together described the ultrasound images and established eight criteria for NFs. The same task was then repeated by two other dermatologists, also with experience in HFU imaging of the skin, independently, to establish inter-observer agreement. A total of 108 NFs in 29 patients were included. Superficial and subcutaneous NFs were hypoechoic with a round to spindle shape. Plexiform NFs were ill-defined, consisting of multiple hypoechoic linear zones. Good to excellent inter-observer agreement was found for six of the eight criteria (k>0.6). This is the first series describing HFU skin imaging of NFs in patients with NF1. Lateral extension that may correspond to involvement of an adjacent nerve seems to be specific to NFs.

Citations

Nov 20, 2019·Pediatric Dermatology·Ana Isabel Rodríguez BanderaRaúl de Lucas Laguna
Jul 11, 2018·Neurology·Ashley CannonDominique C Pichard
Sep 25, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Rossana IzzettiMario Gabriele
May 5, 2020·Dento Maxillo Facial Radiology·Rossana IzzettiDavide Caramella
Jan 15, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Irmina Ranosz-JanickaLigia Brzezińska-Wcisło
Jan 7, 2021·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Elisa de Oliveira BarcauiCarlos Baptista Barcaui
May 4, 2021·Actas dermo-sifiliográficas·H Álvarez-GarridoJ Borbujo
Jul 8, 2021·Neurology·Raquel D ThalheimerUNKNOWN REiNS International Collaboration
Sep 4, 2021·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·Daniela FodorEsperanza Naredo

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