High fructose diet-induced metabolic syndrome: Pathophysiological mechanism and treatment by traditional Chinese medicine

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Ying Pan, Ling-Dong Kong

Abstract

Fructose is a natural monosaccharide broadly used in modern society. Over the past few decades, epidemiological studies have demonstrated that high fructose intake is an etiological factor of metabolic syndrome (MetS). This review highlights research advances on fructose-induced MetS, especially the underlying pathophysiological mechanism as well as pharmacotherapy by traditional Chinese medicine (TCM), using the PubMed, Web of science, China National Knowledge Infrastructure, China Science and Technology Journal and Wanfang Data. This review focuses on de novo lipogenesis (DNL) and uric acid (UA) production, two unique features of fructolysis different from glucose glycolysis. High level of DNL and UA production can result in insulin resistance, the key pathological event in developing MetS, mostly through oxidative stress and inflammation. Some other pathologies like the disturbance in brain and gut microbiota in the development of fructose-induced MetS in the past years, are also discussed. In management of MetS, TCM is an excellent representative in alternative and complementary medicine with a complete theory system and substantial herbal remedies. TCMs against MetS or MetS components, including Chinese patent medicines, T...Continue Reading

Citations

Dec 21, 2018·Critical Reviews in Food Science and Nutrition·Qixing NieShaoping Nie
May 10, 2019·Investigative Ophthalmology & Visual Science·Dingli LuZhijie Li
Jul 14, 2020·Oxidative Medicine and Cellular Longevity·Akinjide Moses AkinnugaAndile Khathi
Jun 2, 2020·Frontiers in Bioengineering and Biotechnology·Zeinab NouriMohammad Abdollahi
Oct 23, 2020·Metabolic Syndrome and Related Disorders·Ozge Tugce PasaogluNurten Turkozkan
Jan 29, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Fernando Gomez-PinillaLuiz Fernando Freire Royes
Jan 14, 2020·Journal of Agricultural and Food Chemistry·Wen-Yuan WuLing-Dong Kong
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