High gamma activity of 60-70 Hz in the area surrounding a cortical tuber in an infant with tuberous sclerosis.

Italian Journal of Pediatrics
Kaori IraharaTaisuke Otsuki

Abstract

To detect the epileptogenic region causing epileptic spasms in an infant with tuberous sclerosis (TS). We applied a multiple band frequency analysis to video electroencephalographic (EEG) recordings of the infant's scalp. We also performed computed tomography (CT), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), and magnetoencephalography (MEG) of the brain in order to ascertain the epileptic focus. During the periodic spasms, we identified fast ictal activity with frequencies of 60-70 Hz in the right centroparietal region. This region was part of the area surrounding the largest cortical tuber that was identified on CT and MRI and was located in the right frontal lobe. An area of increased blood perfusion that was observed with SPECT and dipole sources that were determined with interictal MEG were also located in this area. In addition, ictal frequency oscillations (FOs) with high gamma activity were identified over the cortex surrounding the largest tuber. After a lesionectomy of this tuber, the periodic spasms disappeared, and no FOs were detected over this area. Scalp EEG, which identified the ictal onset zone by detecting fast activity that was suggestive of FOs, was useful for detecti...Continue Reading

References

Apr 23, 2004·Epilepsia·Katsuhiro KobayashiEiji Oka
Oct 29, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tomoyuki AkiyamaO Carter Snead
Jul 7, 2007·Epilepsy & Behavior : E&B·Deepak MadhavanRuben Kuzniecky
Dec 11, 2007·Brain & Development·Takushi InoueYoko Ohtsuka
Feb 22, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hiroshi OtsuboElizabeth J Donner
Sep 30, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Tomoko MizunoMasumi Inagaki

❮ Previous
Next ❯

Citations

Jul 11, 2013·Journal of Autism and Developmental Disorders·Catherine StamoulisCharles A Nelson
Oct 21, 2020·Nature Reviews. Neurology·Rima Nabbout, Mathieu Kuchenbuch

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resections
surgical resection

Software Mentioned

Short Spectrum Eye
MBFA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Ryōikibetsu shōkōgun shirīzu
M Mizuguchi
Transactions of the St. John's Hospital Dermatological Society
Zhonghua er ke za zhi. Chinese journal of pediatrics
Guang-lei TongYun-fei Cai
© 2021 Meta ULC. All rights reserved