High-glycemic index carbohydrates abrogate the antiobesity effect of fish oil in mice

American Journal of Physiology. Endocrinology and Metabolism
Qin HaoLise Madsen

Abstract

Fish oil rich in n-3 polyunsaturated fatty acids is known to attenuate diet-induced obesity and adipose tissue inflammation in rodents. Here we aimed to investigate whether different carbohydrate sources modulated the antiobesity effects of fish oil. By feeding C57BL/6J mice isocaloric high-fat diets enriched with fish oil for 6 wk, we show that increasing amounts of sucrose in the diets dose-dependently increased energy efficiency and white adipose tissue (WAT) mass. Mice receiving fructose had about 50% less WAT mass than mice fed a high fish oil diet supplemented with either glucose or sucrose, indicating that the glucose moiety of sucrose was responsible for the obesity-promoting effect of sucrose. To investigate whether the obesogenic effect of sucrose and glucose was related to stimulation of insulin secretion, we combined fish oil with high and low glycemic index (GI) starches. Mice receiving the fish oil diet containing the low-GI starch had significantly less WAT than mice fed high-GI starch. Moreover, inhibition of insulin secretion by administration of nifedipine significantly reduced WAT mass in mice fed a high-fish oil diet in combination with sucrose. Our data show that the macronutrient composition of the diet mo...Continue Reading

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Citations

May 24, 2013·Adipocyte·Lise Madsen, Karsten Kristiansen
May 16, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Shu WangAlice H Lichtenstein
Dec 18, 2014·American Journal of Physiology. Endocrinology and Metabolism·Qin HaoJacob B Hansen
Mar 31, 2016·American Journal of Physiology. Endocrinology and Metabolism·Pia KiilerichKarsten Kristiansen
Jan 10, 2018·Frontiers in Physiology·Lise MadsenKarsten Kristiansen
Aug 18, 2018·Mediators of Inflammation·Alex S YamashitaWilliam T Festuccia
Jan 12, 2019·Frontiers in Physiology·Lise MadsenKarsten Kristiansen
Jul 12, 2013·The Journal of Nutrition·Haldis H LillefosseBjørn Liaset
Dec 27, 2016·Oxidative Medicine and Cellular Longevity·Nicia Pedreira SoaresFrank Silva Bezerra

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