High-grade astrocytoma (Glioblastoma Multiforme) in an Atlantic spotted dolphin (Stenella frontalis)

Journal of Comparative Pathology
Josué Díaz-DelgadoAntonio Fernández

Abstract

This report describes the gross, microscopical and immunohistochemical features of a high-grade astrocytoma (glioblastoma multiforme) in an adult male Atlantic spotted dolphin (Stenella frontalis). On necropsy examination, a 5 × 2.5 × 2 cm, poorly demarcated, red, friable and locally expansile mass effaced the thalamus and the left periventricular region and extended to the left lateral ventricle of the brain. Microscopically, the mass consisted of haphazardly arranged bundles and rows of interweaving polygonal to spindle-shaped cells. These often palisaded along serpentine foci of necrosis and were surrounded by prominent vessels. Immunohistochemically, the neoplastic cells expressed glial fibrillary acidic protein, but not vimentin, S100 protein, neuron-specific enolase or neurofilament protein. A diagnosis of high-grade astrocytoma was made and this represents the first description of a glioma in a cetacean species.

References

Apr 26, 2007·The American Journal of Pathology·Hiroko Ohgaki, Paul Kleihues
Oct 3, 2007·Mayo Clinic Proceedings·Jan C BucknerJoon H Uhm
Jul 5, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·José A Ramos-VaraUNKNOWN American Association of Veterinary Laboratory Diagnosticians Subcommittee on Standardization of Immunohistochemistry
Nov 10, 2010·Veterinary Pathology·G StoicaK Murphy
Apr 4, 2013·Diseases of Aquatic Organisms·Manuel ArbeloAntonio Fernández
Mar 22, 2014·Journal of Comparative Pathology·M ArbeloA Fernández

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Citations

Jan 26, 2018·Journal of Wildlife Diseases·Maria Domenica PintoreBarbara Iulini
Mar 9, 2018·Frontiers in Molecular Neuroscience·Fangjie Shao, Chong Liu

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