High-grade glioma: can we teach an old dogma new tricks?

Cancer Cell
Richard J Gilbertson

Abstract

The best efforts of clinicians and biologists battling high-grade glioma (HGG) have been overshadowed by two cruel facts: these tumors are essentially incurable and will kill most patients within months, and emergent knowledge of the genetic alterations in HGG has done nothing to ease this burden of suffering. In this issue of Cancer Cell, Phillips et al. report an extensive study of the gene expression profiles of a large cohort of HGG. Their data provide new clues to the origins of this disease and suggest potential targets for novel therapies.

References

Apr 18, 2003·Oncogene·Paul S MischelStanley F Nelson
Sep 18, 2004·Cancer Research·William A FreijeStanley F Nelson
Apr 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yu LiangMark A Israel
May 19, 2005·Cancer Research·Jeremy N RichMike West
Aug 27, 2005·The New England Journal of Medicine·Nader SanaiMitchel S Berger
Jan 7, 2006·Cancer Research·Cho-Lea TsoStanley F Nelson

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Citations

Jun 15, 2014·World Journal of Surgical Oncology·Weiqing WanYouyong Lu
Nov 8, 2006·Medicinal Research Reviews·Jaroslaw JozwiakPawel Wlodarski
Dec 5, 2006·The International Journal of Biochemistry & Cell Biology·Fei He, Yi E Sun

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