High-grade glioma in elderly patients: can the oncogeriatrician help?

Clinical Interventions in Aging
Emeline TabouretFrederique Rousseau

Abstract

Gliomas are the most frequent primary brain tumors in adults. As the population ages in Western countries, the number of people being diagnosed with glioblastoma is expected to increase. Clinical management of elderly patients with primary brain tumors is difficult, owing to multiple comorbidities, polypharmacy, decreased tolerance to chemotherapy, and an increased risk of radiation-induced neurotoxicity. A few specific randomized studies have shown a benefit for radiotherapy in elderly patients with good performance status. For patients with poor performance status, chemotherapy (temozolomide) has been shown to be associated with prolonged duration of response. Patients with methylated O (6)-alkylguanine deoxyribonucleic acid alkyltransferase promoter seem to have better outcomes. Oncogeriatrics proposes the geriatric evaluation of elderly patients to improve therapeutic choices and optimize the management of treatment toxicities and comorbidities.

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May 28, 2014·BioMed Research International·Patrizia FarinaVittorina Zagonel
Nov 5, 2015·International Journal of Radiation Oncology, Biology, Physics·Reza FarjamYue Cao
Dec 4, 2014·Journal of the Neurological Sciences·Uxia Saraiva-EsperónMichel Herranz

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Methods Mentioned

BETA
biopsy
surgical
surgical resection
genetic modifications

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