"High-grade oncocytic renal tumor": morphologic, immunohistochemical, and molecular genetic study of 14 cases

Virchows Archiv : an International Journal of Pathology
Huiying HeOndrej Hes

Abstract

The spectrum of the renal oncocytic tumors has been expanded in recent years to include several novel and emerging entities. We describe a cohort of novel, hitherto unrecognized and morphologically distinct high-grade oncocytic tumors (HOT), currently diagnosed as "unclassified" in the WHO classification. We identified 14 HOT by searching multiple institutional archives. Morphologic, immunohistochemical (IHC), molecular genetic, and molecular karyotyping studies were performed to investigate these tumors. The patients included 3 men and 11 women, with age range from 25 to 73 years (median 50, mean 49 years). Tumor size ranged from 1.5 to 7.0 cm in the greatest dimension (median 3, mean 3.4 cm). The tumors were all pT1 stage. Microscopically, they showed nested to solid growth, and focal tubulocystic architecture. The neoplastic cells were uniform with voluminous oncocytic cytoplasm. Prominent intracytoplasmic vacuoles were frequently seen, but no irregular (raisinoid) nuclei or perinuclear halos were present. All tumors demonstrated prominent nucleoli (WHO/ISUP grade 3 equivalent). Nine of 14 cases were positive for CD117 and cytokeratin (CK) 7 was either negative or only focally positive in of 6/14 cases. All tumors were posit...Continue Reading

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Citations

Mar 29, 2020·The American Journal of Surgical Pathology·Pedram ArganiDoreen N Palsgrove
Jan 8, 2020·Cancers·Reza AlaghehbandanOndrej Hes
Jul 4, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Juan María Roldan-RomeroCristina Rodriguez-Antona
Feb 3, 2021·Mayo Clinic Proceedings·Sounak GuptaJohn C Cheville
Feb 3, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kiril TrpkovOndrej Hes
Mar 9, 2021·Case Reports in Pathology·Noriyoshi IshikawaOsamu Tokunaga
May 16, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Enrico MunariGuido Martignoni
May 20, 2021·Advances in Anatomic Pathology·Nicholas BaniakMichelle S Hirsch
Jul 23, 2021·Expert Review of Anticancer Therapy·Lothar BergmannMarit Ahrens
Sep 2, 2021·Der Pathologe·I PolifkaH Moch
Sep 21, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Payal KapurJames Brugarolas
Jun 9, 2020·Urology·Maher AbdessaterPhilippe Sebe
Sep 23, 2021·Der Pathologe·Arndt Hartmann, Abbas Agaimy

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