High-grade osteosarcoma of the extremity: differences between localized and metastatic tumors at presentation

Journal of Pediatric Hematology/oncology
Gaetano BacciKeith Smith

Abstract

In osteosarcoma, as in other tumors, the presence of metastases at presentation is generally considered a consequence of late diagnosis. To verify this, the authors investigated whether there was a relationship between the stage of the disease at presentation and several clinical and pathologic characteristics, including the interval between the onset of first symptoms or signs and the final diagnosis. One thousand seventy-one patients with high-grade osteosarcoma of the extremity were observed between 1980 and 1999. Of these, 891 had a localized tumor and 180 had metastases at the time of diagnosis. Compared with patients with localized disease, patients with detectable metastases at the time of diagnosis had higher serum levels of alkaline phosphatase, larger primary lesions, and tumors often located in the femur and humerus. In terms of time to diagnosis, the interval between the onset of first symptoms and the final diagnosis was significantly shorter in patients with metastases than in patients with localized tumor. This surprising finding probably reflects a more rapid growth of the tumor. These results suggest a different biologic phenotype and aggressiveness of the tumor in a subgroup of patients and that the stage of t...Continue Reading

References

Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·V GöbelU Göbel
Feb 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A M DavisP J Goodwin
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P A MeyersM LaQuaglia
Jan 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A J ProvisorJ S Miser
Mar 7, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·E D ChristensenG Petterson
Nov 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M B HarrisM P Link
Apr 28, 1999·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L RoncoroniA Peracchia

❮ Previous
Next ❯

Citations

Jun 26, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M WilhelmUNKNOWN ENCCA (European Network for Cancer research in Children and Adolescents)
Mar 2, 2016·Pediatric Blood & Cancer·Tracy A MarkoLogan G Spector
Jul 3, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Andréa Paiva Gadelha GuimarãesFernando Augusto Soares
Jun 13, 2006·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Eleanor HendershotLillian Sung
Mar 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A Sérgio PetrilliUNKNOWN Brazilian Osteosarcoma Treatment Group Studies III and IV
Feb 1, 2006·Expert Review of Anticancer Therapy·Eugene T H Ek, Peter F M Choong
Sep 19, 2014·Clinical Medicine Insights. Pediatrics·Er AbdelkhalekRm Soliman
Aug 4, 2007·The Oncologist·Sean MartinArchie Bleyer
Nov 15, 2016·International Journal of Oncology·Toru OiAkihiro Sudo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.