High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints

International Journal of Molecular Sciences
Michael-Antony LisioCarlos Telleria

Abstract

Among a litany of malignancies affecting the female reproductive tract, that of the ovary is the most frequently fatal. Moreover, while the steady pace of scientific discovery has fuelled recent ameliorations in the outcomes of many other cancers, the rates of mortality for ovarian cancer have been stagnant since around 1980. Yet despite the grim outlook, progress is being made towards better understanding the fundamental biology of this disease and how its biology in turn influences clinical behaviour. It has long been evident that ovarian cancer is not a unitary disease but rather a multiplicity of distinct malignancies that share a common anatomical site upon presentation. Of these, the high-grade serous subtype predominates in the clinical setting and is responsible for a disproportionate share of the fatalities from all forms of ovarian cancer. This review aims to provide a detailed overview of the clinical-pathological features of ovarian cancer with a particular focus on the high-grade serous subtype. Along with a description of the relevant clinical aspects of this disease, including novel trends in treatment strategies, this text will inform the reader of recent updates to the scientific literature regarding the origin...Continue Reading

References

May 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K SwenertonG MacLean
Oct 15, 1987·Cancer·T ThigpenR McGehee
Jan 1, 1985·Gynecologic Oncology·J A LopezB F Issell
Jul 17, 1971·Lancet·M F Fathalla
Sep 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J T ThigpenR J Barrett
Dec 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P FrancisM Markman
Jun 24, 1998·British Journal of Obstetrics and Gynaecology·J F StrattonB A Ponder
Aug 30, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P NeijtH C van Houwelingen
Sep 4, 2003·Journal of the National Cancer Institute·Andreas du BoisUNKNOWN Arbeitsgemeinschaft Gynäkologische Onkologie Ovarian Cancer Study Group
Sep 10, 2003·Hematology/oncology Clinics of North America·Maurie Markman
Dec 6, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M A BookmanR F Ozols
Apr 28, 2004·The American Journal of Pathology·Ie-Ming Shih, Robert J Kurman
Nov 27, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Tanya J ShawBarbara C Vanderhyden
May 3, 2005·Nature Reviews. Cancer·Honami Naora, Denise J Montell
Aug 20, 2005·Nature Reviews. Cancer·William G Kaelin
Sep 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rebecca T MarquezKaren H Lu
Nov 1, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Noriko KatoTeiichi Motoyama
Jan 6, 2006·The New England Journal of Medicine·Deborah K ArmstrongUNKNOWN Gynecologic Oncology Group
Jan 26, 2006·The American Journal of Surgical Pathology·Fabiola MedeirosChristopher P Crum
Jan 27, 2007·The American Journal of Surgical Pathology·David W KindelbergerChristopher P Crum
Jun 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Scott ShellMarcus E Peter
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard W TothillDavid D L Bowtell
May 23, 2009·Nature Reviews. Cancer·Robert C BastGordon B Mills
Oct 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ursula A MatulonisRichard T Penson
Feb 16, 2010·The American Journal of Surgical Pathology·Robert J Kurman, Ie-Ming Shih
Mar 17, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Aparna MahajanJian-Jun Wei
Apr 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter C FongStan B Kaye
May 1, 2010·The American Journal of Surgical Pathology·Elisabetta KuhnIe-Ming Shih
Jul 24, 2010·The American Journal of Pathology·Ernst Lengyel
Sep 8, 2010·The New England Journal of Medicine·Ignace VergoteUNKNOWN NCIC Clinical Trials Group
Oct 5, 2010·Lancet·Gordon J S RustinUNKNOWN EORTC 55955 investigators
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman

❮ Previous
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Citations

Jan 16, 2020·Cells·Cristina Elena StaicuSilviu-Cristian Voinea
Feb 13, 2020·Diagnostics·Chloe KarpinskyjAleksandra Gentry-Maharaj
Mar 4, 2020·Cancers·Sudipta PathakEdyta Paradowska
Jun 10, 2020·Cancers·Elena AlexandrovaRoberta Tarallo
Aug 18, 2020·Insights Into Imaging·Paula Martin-GonzalezEvis Sala
Jul 16, 2020·Journal of Cellular and Molecular Medicine·Mingyang BaoYueqing Hu
Oct 28, 2019·Pharmaceutics·Rossella FarraGabriele Grassi
Aug 14, 2020·Cancers·Laura CaraviaSilviu Cristian Voinea
Sep 24, 2020·Cancers·Alexander Jorge CortezKatarzyna Marta Lisowska
Nov 17, 2019·International Journal of Molecular Sciences·Josep Marí-AlexandreJuan Gilabert-Estellés
May 10, 2020·Journal of Experimental & Clinical Cancer Research : CR·Jing ZhangDan Jiang
Mar 26, 2020·Cell Biology International·Caglar Berkel, Ercan Cacan
Jun 21, 2020·International Journal of Molecular Sciences·Alexandra McMellenMarisa R Moroney
Sep 26, 2020·Frontiers in Oncology·Ram N GanapathiMahrukh K Ganapathi
Aug 23, 2020·Communications Biology·Sherif BayoumyKim Pettersson
Apr 1, 2020·International Journal of Environmental Research and Public Health·Chen-Yu HuangPeng-Hui Wang
Dec 18, 2019·Histopathology·Anthony T Williams, Raji Ganesan
Feb 29, 2020·Indian Journal of Pathology & Microbiology·Abhilash DeoPritha Ray
Aug 25, 2020·Case Reports in Surgery·Chad PurcellMartin Corsten
Nov 28, 2020·Journal for Immunotherapy of Cancer·Diana Canals HernaezKelly M McNagny
Dec 17, 2020·CA: a Cancer Journal for Clinicians·Lynne W ElmoreWilliam C Phelps
Jan 3, 2021·Molecular Biotechnology·Precilla S DaisyT S Anitha
Feb 9, 2021·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Júlia Teixeira de OliveiraFabio Vieira Dos Santos
Oct 30, 2020·Cancer Management and Research·Ioannis A Voutsadakis
Dec 4, 2020·International Journal of Molecular Sciences·Agnieszka SzyposzynskaAleksandra Klimczak
Jan 31, 2021·Diagnostics·Jason VincentSusann M Brady-Kalnay

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Methods Mentioned

BETA
hysterectomy
prophylactic surgery
biopsies
biopsy
exome sequencing
dissection
total resection
transfection
xenografts
surgical resection

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