High-grade soft tissue sarcomas of the extremities: surgical margins influence only local recurrence not overall survival

International Orthopaedics
Julie WilleumierMichiel van de Sande

Abstract

After surgical treatment of high-grade soft tissue sarcomas, local recurrences, metastases and survival remain a great concern. Further knowledge on factors with a possible impact on these endpoints, specifically resection margins, is relevant for decision-making regarding the aggressiveness of local treatment. The aim of this study is to investigate the impact of prognostic factors on local recurrence and overall survival for patients with high-grade soft tissue sarcomas of the extremities. In a retrospective cohort study of 127 patients (mean age 48 years, range five to 91; median follow-up 71 months) the prognostic effect of margin status and other clinicopathologic characteristics on local recurrence and overall survival were analysed by employing a multivariate Cox regression. Five-year cumulative incidence of local recurrence and distant metastases was 26% and 40%, respectively. The estimated five-year overall survival was 59%. Tumour size proved a consistent adverse prognostic factor for local recurrence (hazard ratio (HR) 3.9), distant metastasis (HR 4.9) and overall survival (HR 2.4). The significant association of resection margins with local recurrence (HR 10.2) was confirmed. Margins were however not significantly a...Continue Reading

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Citations

Mar 1, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D A MüllerR Capanna
Dec 6, 2017·Innovative Surgical Sciences·Kamran Harati, Marcus Lehnhardt
Apr 22, 2020·European Radiology·Anna HirschmannJohan L Bloem
May 1, 2021·Cancers·Andrea SambriMassimiliano De Paolis
Jul 31, 2020·Current Medical Imaging·Paolo SpinnatoGiuseppe Bianchi

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